2. Gene
  3. RIC8B - RIC8 guanine nucleotide exchange factor B Gene

RIC8B - RIC8 guanine nucleotide exchange factor B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RIC8; hSyn

Gene ID: 55188 | Gene type: protein coding

About RIC8B

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,774,682-106,889,316 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 2.6), gall bladder (RPKM 2.0) and 25 other tissues.

Summary

Enables G-protein alpha-subunit binding activity. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RIC8B Products(10)

mRNA Protein Name
NM_001330145.2 NP_001317074.1 synembryn-B isoform 1
NM_001330146.2 NP_001317075.1 synembryn-B isoform 2
NM_001330147.2 NP_001317076.1 synembryn-B isoform 3
NM_001351361.2 NP_001338290.1 synembryn-B isoform 5
NM_001351362.2 NP_001338291.1 synembryn-B isoform 6
NM_001351363.2 NP_001338292.1 synembryn-B isoform 7
NM_001351364.2 NP_001338293.1 synembryn-B isoform 8
NM_001351366.2 NP_001338295.1 synembryn-B isoform 9
NM_001351367.2 NP_001338296.1 synembryn-B isoform 10
NM_018157.4 NP_060627.2 synembryn-B isoform 4

RIC8B Protein Structure

Ric8

Ric8: Guanine nucleotide exchange factor synembryn (66 - 483)

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  • 520 a.a.
Protein Preferred Names Protein Names

synembryn-B

brain synembrin

Related Diseases

Diseases Alias
Epithelial-Stromal Tgfbi Dystrophy
Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V
Pain Agnosia

Analgesia
Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11968 RIC8B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RIC8B MGD MGI:2682307
Canis familiaris RIC8B VGNC VGNC:45573
Rattus norvegicus RIC8B RGD RGD:631419
Bos taurus RIC8B VGNC VGNC:33962
Felis catus RIC8B VGNC VGNC:64625
Macaca mulatta RIC8B VGNC VGNC:76822