USP40 - ubiquitin specific peptidase 40 Gene

Homo sapiens

Gene ID: 55230 | Gene type: protein coding

About USP40

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,475,526-233,566,782 (from NCBI)

This gene has 17 transcripts (splice variants), 191 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 7.5), thyroid (RPKM 6.8) and 25 other tissues.

Summary

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating Enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating Enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

USP40 Products(11)

mRNA	Protein	Name
NM_001365479.2	NP_001352408.1	ubiquitin carboxyl-terminal hydrolase 40 isoform 1
NM_001382295.1	NP_001369224.1	ubiquitin carboxyl-terminal hydrolase 40 isoform 1
NM_001382296.1	NP_001369225.1	ubiquitin carboxyl-terminal hydrolase 40 isoform 3
NM_001382297.1	NP_001369226.1	ubiquitin carboxyl-terminal hydrolase 40 isoform 4
NM_001382298.1	NP_001369227.1	ubiquitin carboxyl-terminal hydrolase 40 isoform 5
NM_001382299.1	NP_001369228.1	ubiquitin carboxyl-terminal hydrolase 40 isoform 6
NM_001382300.1	NP_001369229.1	ubiquitin carboxyl-terminal hydrolase 40 isoform 7
NM_001382301.1	NP_001369230.1	ubiquitin carboxyl-terminal hydrolase 40 isoform 8
NM_001382302.1	NP_001369231.1	ubiquitin carboxyl-terminal hydrolase 40 isoform 9
NM_001382303.1	NP_001369232.1	ubiquitin carboxyl-terminal hydrolase 40 isoform 10
NM_018218.4	NP_060688.2	ubiquitin carboxyl-terminal hydrolase 40 isoform 2

USP40 Protein Structure

UCH

0
200
400
600
800
1000
1235 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 40

deubiquitinating enzyme 40

Related Diseases

Diseases

Alias

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15552	USP40 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	USP40	VGNC	VGNC:52845
Mus musculus	USP40	MGD	MGI:2443184
Macaca mulatta	USP40	VGNC	VGNC:79226
Rattus norvegicus	USP40	RGD	RGD:1309613

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