TMEM39A - transmembrane protein 39A Gene

Homo sapiens

Also known as SUSR2

Gene ID: 55254 | Gene type: protein coding

About TMEM39A

This gene has 12 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 7.9), placenta (RPKM 6.8) and 25 other tissues.

Summary

Involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of viral genome replication. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM39A Products(1)

mRNA	Protein	Name
NM_018266.3	NP_060736.1	transmembrane protein 39A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	31806350	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	31806350	GOA
involved in negative regulation of autophagosome maturation	IMP IMP: Inferred from mutant phenotype	31806350	GOA
involved in positive regulation of viral genome replication	IDA IDA: Inferred from direct assay	31849860	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	31806350	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM39A Protein Structure

Tmp39

0
100
200
300
400
488 a.a.

Protein Preferred Names

Protein Names

transmembrane protein 39A

suppressor of SQST-1 aggregates in rpl-43 mutants

Related Diseases

Diseases

Alias

Dowling-Degos Disease

Reticular Pigment Anomaly Of Flexures	Dark Dot Disease
Reticulate Acropigmentation Of Kitamura	Dowling-Degos Kitamura Disease
Kitamura Reticulate Acropigmentation	Ddd
Dowling-Degos-Kitamura Disease	Reticular Pigmented Anomaly Of Flexures

Adams-Oliver Syndrome

Adams Oliver Syndrome	Aos
Congenital Scalp Defects With Distal Limb Reduction Anomalies	Aplasia Cutis Congenita With Terminal Transverse Limb Defects
Congenital Scalp Defects With Distal Limb Anomalies	Limb, Scalp And Skull Defects
Limb Scalp And Skull Defects	Absence Defect Of Limbs, Scalp, And Skull

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14721	TMEM39A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMEM39A	VGNC	VGNC:66343
Macaca mulatta	TMEM39A	VGNC	VGNC:79517
Canis familiaris	TMEM39A	VGNC	VGNC:47576
Bos taurus	TMEM39A	VGNC	VGNC:36082
Rattus norvegicus	TMEM39A	RGD	RGD:1306421
Mus musculus	TMEM39A	MGD	MGI:1915096

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