FGGY - FGGY carbohydrate kinase domain containing Gene

Homo sapiens

Gene ID: 55277 | Gene type: protein coding

About FGGY

Cytogenetic location: 1p32.1 Genomic coordinates (GRCh38): 1:59,296,378-59,762,730 (from NCBI)

This gene has 25 transcripts (splice variants), 204 orthologues and 6 paralogues. Ubiquitous expression in liver (RPKM 2.1), kidney (RPKM 1.3) and 25 other tissues.

Summary

This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of Other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

FGGY Products(14)

mRNA	Protein	Name
NM_001113411.2	NP_001106882.1	FGGY carbohydrate kinase domain-containing protein isoform a
NM_001244714.2	NP_001231643.1	FGGY carbohydrate kinase domain-containing protein isoform c
NM_001278224.2	NP_001265153.1	FGGY carbohydrate kinase domain-containing protein isoform d
NM_001350790.2	NP_001337719.1	FGGY carbohydrate kinase domain-containing protein isoform a
NM_001350791.2	NP_001337720.1	FGGY carbohydrate kinase domain-containing protein isoform b
NM_001350792.2	NP_001337721.1	FGGY carbohydrate kinase domain-containing protein isoform e
NM_001350793.2	NP_001337722.1	FGGY carbohydrate kinase domain-containing protein isoform e
NM_001350794.2	NP_001337723.1	FGGY carbohydrate kinase domain-containing protein isoform f
NM_001350795.2	NP_001337724.1	FGGY carbohydrate kinase domain-containing protein isoform g
NM_001350796.2	NP_001337725.1	FGGY carbohydrate kinase domain-containing protein isoform h
NM_001350797.2	NP_001337726.1	FGGY carbohydrate kinase domain-containing protein isoform i
NM_001350798.2	NP_001337727.1	FGGY carbohydrate kinase domain-containing protein isoform j
NM_001350799.2	NP_001337728.1	FGGY carbohydrate kinase domain-containing protein isoform k
NM_018291.5	NP_060761.3	FGGY carbohydrate kinase domain-containing protein isoform b

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in carbohydrate phosphorylation	IDA IDA: Inferred from direct assay	27909055	GOA
involved in neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	17671248	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGGY Protein Structure

FGGY_N

FGGY_C

0
100
200
300
400
500
551 a.a.

Protein Preferred Names

Protein Names

FGGY carbohydrate kinase domain-containing protein

D-ribulokinase

Related Diseases

Diseases

Alias

Lateral Sclerosis

Primary Lateral Sclerosis	Adult-Onset Primary Lateral Sclerosis
Adult-Onset Pls	Motor Neuron Disease
Pls	Pls - [Primary Lateral Sclerosis]
Lateral Spinal Sclerosis	Lateral Complete Paralysis
Lateral Incomplete Paralysis	Lateral Paralysis

Spastic Paraplegia 7, Autosomal Recessive

SPG7	Hereditary Spastic Paraplegia 7
Spastic Paraplegia Type 7	Spastic Paraplegia 7
Hereditary Spastic Paraplegia, Paraplegin Type	Autosomal Recessive Spastic Paraplegia 7
Hereditary Spastic Paraplegia Paraplegin Type	Spastic Paraplegia-7
Paraplegia, Spastic, Autosomal Recessive, Type 7	Spastic Paraplegia, Hereditary
Autosomal Recessive Hereditary Spastic Paraplegia

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Glycerol Kinase Deficiency

Hyperglycerolemia	GKD
Gk Deficiency	Gk1 Deficiency
Deficiency Of Glycerol Kinase	Isolated Glycerol Kinase Deficiency
Glycerol Kinase Deficiency, Adult Form	Glycerol Kinase Deficiency, Juvenile Form
Deficiency, Glycerol Kinase

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04926	FGGY Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FGGY	VGNC	VGNC:28991
Macaca mulatta	FGGY	VGNC	VGNC:72576
Rattus norvegicus	FGGY	RGD	RGD:1359429
Canis familiaris	FGGY	VGNC	VGNC:40863
Mus musculus	FGGY	MGD	MGI:1922828

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