PI4K2B - phosphatidylinositol 4-kinase type 2 beta Gene

Homo sapiens

Also known as PIK42B; PI4KIIB

Gene ID: 55300 | Gene type: protein coding

About PI4K2B

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:25,234,033-25,279,204 (from NCBI)

This gene has 2 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 18.2), small intestine (RPKM 15.4) and 25 other tissues.

Summary

This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016]

PI4K2B Products(1)

mRNA	Protein	Name
NM_018323.4	NP_060793.2	phosphatidylinositol 4-kinase type 2-beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol 4-kinase activity	IDA IDA: Inferred from direct assay	11923287	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in phosphatidylinositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	11923287	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	11923287	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12324459	GOA
located in early endosome membrane	IDA IDA: Inferred from direct assay	11923287	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	12324459	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12324459	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PI4K2B Protein Structure

PI3_PI4_kinase

0
100
200
300
400
481 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 4-kinase type 2-beta

PI4KII-BETA

Related Diseases

Diseases

Alias

Macrocephaly/Autism Syndrome

Macrocephaly-Autism Syndrome	Macrocephaly-Intellectual Disability-Autism Syndrome
MCEPHAS

Developmental And Epileptic Encephalopathy 53

DEE53	Epileptic Encephalopathy, Early Infantile, 53
Eiee53	Developmental And Epileptic Encephalopathy, 53
Early Infantile Epileptic Encephalopathy 53

Parkinson Disease 20, Early-Onset

Early-Onset Parkinson Disease 20	PARK20
Parkinson'S Disease 20	Early-Onset Parkinson'S Disease 20
Parkinson Disease, Type 20, Early-Onset

Post-Vaccinal Encephalitis

Encephalitis Following Immunization Procedures	Postvaccinal Encephalomyelitis
Encephalomyelitis, Acute Disseminated

Adams-Oliver Syndrome

Adams Oliver Syndrome	Aos
Congenital Scalp Defects With Distal Limb Reduction Anomalies	Aplasia Cutis Congenita With Terminal Transverse Limb Defects
Congenital Scalp Defects With Distal Limb Anomalies	Limb, Scalp And Skull Defects
Limb Scalp And Skull Defects	Absence Defect Of Limbs, Scalp, And Skull

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10465	PI4K2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PI4K2B	VGNC	VGNC:110547
Bos taurus	PI4K2B	VGNC	VGNC:97298
Felis catus	PI4K2B	VGNC	VGNC:82521
Mus musculus	PI4K2B	MGD	MGI:1914323
Canis familiaris	PI4K2B	VGNC	VGNC:97213
Rattus norvegicus	PI4K2B	RGD	RGD:1359515
Others	PI4K2B	NCBI

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