LARP6 - La ribonucleoprotein 6, translational regulator Gene

Homo sapiens

Also known as ACHN

Gene ID: 55323 | Gene type: protein coding

About LARP6

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:70,829,130-70,854,157 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and 6 paralogues. Broad expression in brain (RPKM 22.8), thyroid (RPKM 15.1) and 17 other tissues.

Summary

Enables RNA binding activity and Myosin binding activity. Involved in positive regulation of collagen biosynthetic process; positive regulation of mRNA binding activity; and positive regulation of translation. Located in nucleus. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022]

LARP6 Products(3)

mRNA	Protein	Name
NM_001286679.2	NP_001273608.1	la-related protein 6 isoform 3
NM_018357.4	NP_060827.2	la-related protein 6 isoform 1
NM_197958.3	NP_932062.1	la-related protein 6 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA stem-loop binding	IDA IDA: Inferred from direct assay	20603131	GOA
enables RNA stem-loop binding	IMP IMP: Inferred from mutant phenotype	21746880	GOA
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	20603131	GOA
enables mRNA 5'-UTR binding	IMP IMP: Inferred from mutant phenotype	21746880	GOA
enables myosin binding	IPI IPI: Inferred from physical interaction	20603131	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20603131	GOA
enables sequence-specific mRNA binding	IDA IDA: Inferred from direct assay	22190748	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	21746880	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20603131	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	21746880	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21746880	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LARP6 Protein Structure

SUZ-C

0
100
200
300
400
491 a.a.

Protein Preferred Names

Protein Names

la-related protein 6

La ribonucleoprotein domain family member 6

Related Diseases

Diseases

Alias

Ovarian Endometrial Cancer

Endometrioid Neoplasm Of Ovary	Malignant Ovarian Endometrioid Tumor
Ovarian Endometrioid Neoplasm

Retrograde Amnesia

Amnesia, Retrograde

Brittle Bone Disorder

Osteogenesis Imperfecta	Brittle Bone Disease
Fragilitas Ossium	Osteopsathyrosis
Lobstein Disease	Oi
Vrolik Disease	Lobstein'S Disease
Lobstein'S Syndrome	Vrolik'S Disease
Porak And Durante Disease	Glass Bone Disease
Osteogenesis Imperfecta, Dominant Perinatal Lethal	Osteogenesis Imperfecta, Recessive Perinatal Lethal
Brittle Bone Syndrome	Oi - [Osteogenesis Imperfecta]
Ossium Fragility	Osteitis Fragilitans
Bony Fragility	Blue Sclera With Fragility Of Bone And Deafness
White Blue Sclera - Fragility Of Bone - Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07530	LARP6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LARP6	VGNC	VGNC:63195
Mus musculus	LARP6	MGD	MGI:1914807
Rattus norvegicus	LARP6	RGD	RGD:1308414
Canis familiaris	LARP6	VGNC	VGNC:42590
Bos taurus	LARP6	VGNC	VGNC:30793
Macaca mulatta	LARP6	VGNC	VGNC:74107

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