1. Gene
  2. LARP6 - La ribonucleoprotein 6, translational regulator Gene

LARP6 - La ribonucleoprotein 6, translational regulator Gene

Homo sapiens

Also known as ACHN

Gene ID: 55323 | Gene type: protein coding

About LARP6

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:70,829,130-70,854,157 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and 6 paralogues. Broad expression in brain (RPKM 22.8), thyroid (RPKM 15.1) and 17 other tissues.

Summary

Enables RNA binding activity and Myosin binding activity. Involved in positive regulation of collagen biosynthetic process; positive regulation of mRNA binding activity; and positive regulation of translation. Located in nucleus. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022]

LARP6 Products(3)

mRNA Protein Name
NM_001286679.2 NP_001273608.1 la-related protein 6 isoform 3
NM_018357.4 NP_060827.2 la-related protein 6 isoform 1
NM_197958.3 NP_932062.1 la-related protein 6 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA stem-loop binding IDA
IDA: Inferred from direct assay
20603131 GOA
enables RNA stem-loop binding IMP
IMP: Inferred from mutant phenotype
21746880 GOA
enables mRNA 5'-UTR binding IDA
IDA: Inferred from direct assay
20603131 GOA
enables mRNA 5'-UTR binding IMP
IMP: Inferred from mutant phenotype
21746880 GOA
enables myosin binding IPI
IPI: Inferred from physical interaction
20603131 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20603131 GOA
enables sequence-specific mRNA binding IDA
IDA: Inferred from direct assay
22190748 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
21746880 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20603131 GOA
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
21746880 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21746880 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LARP6 Protein Structure

La

La: La domain (96 - 155)

SUZ-C

SUZ-C: SUZ-C motif (452 - 482)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
Protein Preferred Names Protein Names

la-related protein 6

La ribonucleoprotein domain family member 6

Related Diseases

Diseases Alias
Ovarian Endometrial Cancer

Endometrioid Neoplasm Of Ovary

Malignant Ovarian Endometrioid Tumor

Ovarian Endometrioid Neoplasm

Retrograde Amnesia

Amnesia, Retrograde

Brittle Bone Disorder

Osteogenesis Imperfecta

Brittle Bone Disease

Fragilitas Ossium

Osteopsathyrosis

Lobstein Disease

Oi

Vrolik Disease

Lobstein'S Disease

Lobstein'S Syndrome

Vrolik'S Disease

Porak And Durante Disease

Glass Bone Disease

Osteogenesis Imperfecta, Dominant Perinatal Lethal

Osteogenesis Imperfecta, Recessive Perinatal Lethal

Brittle Bone Syndrome

Oi - [Osteogenesis Imperfecta]

Ossium Fragility

Osteitis Fragilitans

Bony Fragility

Blue Sclera With Fragility Of Bone And Deafness

White Blue Sclera - Fragility Of Bone - Deafness

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus LARP6 VGNC VGNC:63195
Mus musculus LARP6 MGD MGI:1914807
Rattus norvegicus LARP6 RGD RGD:1308414
Canis familiaris LARP6 VGNC VGNC:42590
Bos taurus LARP6 VGNC VGNC:30793
Macaca mulatta LARP6 VGNC VGNC:74107