2. Gene
  3. WDR33 - WD repeat domain 33 Gene

WDR33 - WD repeat domain 33 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NET14; WDC146

Gene ID: 55339 | Gene type: protein coding

About WDR33

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,701,027-127,811,171 (from NCBI)

This gene has 5 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in testis (RPKM 5.8), lymph node (RPKM 4.9) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

WDR33 Products(3)

mRNA Protein Name
NM_001006622.3 NP_001006623.1 pre-mRNA 3' end processing protein WDR33 isoform 2
NM_001006623.4 NP_001006624.1 pre-mRNA 3' end processing protein WDR33 isoform 3
NM_018383.5 NP_060853.3 pre-mRNA 3' end processing protein WDR33 isoform 1
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
11162572 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR33 Protein Structure

WD40

WD40: WD domain, G-beta repeat (155 - 188)

WD40

WD40: WD domain, G-beta repeat (195 - 230)

WD40

WD40: WD domain, G-beta repeat (238 - 266)

WD40

WD40: WD domain, G-beta repeat (279 - 316)

WD40

WD40: WD domain, G-beta repeat (322 - 360)

WD40

WD40: WD domain, G-beta repeat (373 - 402)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (673 - 727)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (715 - 770)

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  • 1336 a.a.
Protein Preferred Names Protein Names

pre-mRNA 3' end processing protein WDR33

WD repeat-containing protein 33

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15773 WDR33 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus WDR33 VGNC VGNC:36892
Macaca mulatta WDR33 VGNC VGNC:79526
Rattus norvegicus WDR33 RGD RGD:1309230
Felis catus WDR33 VGNC VGNC:67026
Canis familiaris WDR33 VGNC VGNC:48360
Mus musculus WDR33 MGD MGI:1921570