TMEM63B - transmembrane protein 63B Gene

Homo sapiens

Also known as C6orf110

Gene ID: 55362 | Gene type: protein coding

About TMEM63B

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,126,633-44,155,519 (from NCBI)

This gene has 10 transcripts (splice variants), 309 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 21.2), testis (RPKM 16.9) and 25 other tissues.

Summary

Predicted to enable calcium activated cation channel activity; mechanosensitive ion channel activity; and osmolarity-sensing cation channel activity. Predicted to be involved in cation transmembrane transport. Located in actin Cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM63B Products(2)

mRNA	Protein	Name
NM_001318792.1	NP_001305721.1	CSC1-like protein 2
NM_018426.3	NP_060896.1	CSC1-like protein 2

TMEM63B Protein Structure

RSN1_TM

PHM7_cyt

RSN1_7TM

0
200
400
600
832 a.a.

Protein Preferred Names

Protein Names

CSC1-like protein 2

Related Diseases

Diseases

Alias

Gordon Holmes Syndrome

Cerebellar Ataxia And Hypogonadotropic Hypogonadism	Lhrh Deficiency And Ataxia
Cerebellar Ataxia-Hypogonadism Syndrome	GDHS
Cahh	Luteinizing Hormone-Releasing Hormone Deficiency With Ataxia
Gordon-Holmes Syndrome	Deficiency Of Luteinizing Hormone-Releasing Hormone With Ataxia
Luteinizing Hormone-Releasing Hormone, Deficiency Of, With Ataxia	Cerebellar Ataxia - Hypogonadism
Luteinizing Hormone Releasing Hormone, Deficiency Of With Ataxia	Ataxia, Cerebellar, And Hypogonadotropic Hypogonadism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14733	TMEM63B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TMEM63B	VGNC	VGNC:36104
Macaca mulatta	TMEM63B	VGNC	VGNC:79084
Rattus norvegicus	TMEM63B	RGD	RGD:1305862
Canis familiaris	TMEM63B	VGNC	VGNC:47596
Felis catus	TMEM63B	VGNC	VGNC:66356
Mus musculus	TMEM63B	MGD	MGI:2387609

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