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  3. DNAH3 - dynein axonemal heavy chain 3 Gene

DNAH3 - dynein axonemal heavy chain 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HDHC8; HEL-36; DNAHC3B; HSADHC3; DNAHC3-B

Gene ID: 55567 | Gene type: protein coding

About DNAH3

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:20,933,111-21,159,459 (from NCBI)

This gene has 8 transcripts (splice variants), 281 orthologues and 15 paralogues. Biased expression in testis (RPKM 2.3), lung (RPKM 0.6) and 4 other tissues.

Summary

This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]

DNAH3 Products(3)

mRNA Protein Name
NM_001347886.2 NP_001334815.1 dynein axonemal heavy chain 3 isoform 2
NM_001394581.1 NP_001381510.1 dynein axonemal heavy chain 3 isoform 3
NM_017539.2 NP_060009.1 dynein axonemal heavy chain 3 isoform 1

DNAH3 Protein Structure

DHC_N2

DHC_N2: Dynein heavy chain, N-terminal region 2 (864 - 1269)

AAA_6

AAA_6: Hydrolytic ATP binding site of dynein motor region D1 (1391 - 1618)

AAA_7

AAA_7: P-loop containing dynein motor region D3 (2047 - 2306)

AAA_8

AAA_8: P-loop containing dynein motor region D4 (2401 - 2665)

MT

MT: Microtubule-binding stalk of dynein motor (2678 - 3023)

AAA_9

AAA_9: ATP-binding dynein motor region D5 (3046 - 3273)

Dynein_heavy

Dynein_heavy: Dynein heavy chain and region D6 of dynein motor (3405 - 4113)

  • 0
  • 700
  • 1400
  • 2100
  • 2800
  • 3500
  • 4116 a.a.
Protein Preferred Names Protein Names

dynein axonemal heavy chain 3

axonemal beta dynein heavy chain 3

Related Diseases

Diseases Alias
Sulfonamide Allergy
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03849 DNAH3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DNAH3 VGNC VGNC:61544
Macaca mulatta DNAH3 VGNC VGNC:71941
Canis familiaris DNAH3 VGNC VGNC:40015
Bos taurus DNAH3 VGNC VGNC:57348
Mus musculus DNAH3 MGD MGI:2683040
Rattus norvegicus DNAH3 RGD RGD:1305855