YEATS2 - YEATS domain containing 2 Gene

Homo sapiens

Also known as FAME4

Gene ID: 55689 | Gene type: protein coding

About YEATS2

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:183,697,797-183,812,624 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 7.4), brain (RPKM 7.1) and 25 other tissues.

Summary

Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

YEATS2 Products(4)

mRNA	Protein	Name
NM_001351369.2	NP_001338298.1	YEATS domain-containing protein 2 isoform 3
NM_001351370.2	NP_001338299.1	YEATS domain-containing protein 2 isoform 1
NM_001351371.2	NP_001338300.1	YEATS domain-containing protein 2 isoform 2
NM_018023.5	NP_060493.3	YEATS domain-containing protein 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables TBP-class protein binding	IPI IPI: Inferred from physical interaction	18838386	GOA
enables histone binding	IDA IDA: Inferred from direct assay	27103431	GOA
enables histone reader activity	IDA IDA: Inferred from direct assay	27103431	GOA
enables modification-dependent protein binding	IDA IDA: Inferred from direct assay	27103431	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18838386	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	18838386	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18838386	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19936620	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19103755	GOA
involved in regulation of cell division	IDA IDA: Inferred from direct assay	20562830	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22055187	GOA
involved in regulation of tubulin deacetylation	IMP IMP: Inferred from mutant phenotype	20562830	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ATAC complex	IDA IDA: Inferred from direct assay	18838386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YEATS2 Protein Structure

YEATS

0
300
600
900
1200
1422 a.a.

Protein Preferred Names

Protein Names

YEATS domain-containing protein 2

Related Diseases

Diseases

Alias

Epilepsy, Familial Adult Myoclonic, 4

FAME4	Fcmte4
Cortical Myoclonic Tremor With Epilepsy, Familial, 4	Familial Adult Myoclonic Epilepsy 4
Epilepsy, Myoclonic, Familial Adult, 4	Familial Cortical Myoclonic Tremor And Epilepsy 4
Epilepsy, Myoclonic, Familial Adult, Type 4

Familial Adult Myoclonic Epilepsy

Benign Adult Familial Myoclonus Epilepsy	Bafme
Benign Adult Familial Myoclonic Epilepsy	Fame
Familial Cortical Myoclonic Tremor And Epilepsy	Fcmte
Adcme	Autosomal Dominant Cortical Myoclonus And Epilepsy
Fam	Epilepsy, Myoclonic, Familial Adult
Epilepsy, Myoclonic, Benign Adult Familial, Type 2

Epilepsy, Familial Adult Myoclonic, 7

FAME7	Bafme7
Fcmte7	Benign Adult Familial Myoclonic Epilepsy 7
Cortical Myoclonic Tremor With Epilepsy, Familial, 7	Familial Adult Myoclonic Epilepsy 7
Familial Cortical Myoclonic Tremor And Epilepsy 7	Benign Adult Familial Myoclonic Epilepsy 27
Epilepsy, Myoclonic, Familial Adult, Type 7

Epilepsy, Familial Adult Myoclonic, 1

FAME1	Benign Adult Familial Myoclonic Epilepsy 1
Bafme1	Fcmte1
Cortical Myoclonic Tremor With Epilepsy, Familial, 1	Familial Adult Myoclonic Epilepsy 1
Familial Cortical Myoclonic Tremor And Epilepsy 1	Epilepsy, Myoclonic, Familial Adult, Type 1

Epilepsy, Familial Adult Myoclonic, 3

FAME3	Fcmte3
Cortical Myoclonic Tremor With Epilepsy, Familial, 3	Familial Adult Myoclonic Epilepsy 3
Familial Cortical Myoclonic Tremor And Epilepsy 3	Epilepsy, Myoclonic, Familial Adult, Type 3

Epilepsy, Familial Adult Myoclonic, 2

FAME2	Benign Adult Familial Myoclonic Epilepsy 2
Bafme2	Fcmte2
Adcme	Cortical Myoclonic Tremor With Epilepsy, Familial, 2
Cortical Myoclonus And Epilepsy, Autosomal Dominant	Familial Adult Myoclonic Epilepsy 2
Epilepsy, Myoclonic, Benign Adult Familial, Type 2	Autosomal Dominant Cortical Myoclonus And Epilepsy
Familial Cortical Myoclonic Tremor And Epilepsy 2	Epilepsy, Myoclonic, Familial Adult, Type 2

Epilepsy, Familial Adult Myoclonic, 6

FAME6	Benign Adult Familial Myoclonic Epilepsy 6
Bafme6	Fcmte6
Cortical Myoclonic Tremor With Epilepsy, Familial, 6	Familial Adult Myoclonic Epilepsy 6
Familial Cortical Myoclonic Tremor And Epilepsy 6	Epilepsy, Myoclonic, Familial Adult, Type 6

Macular Dystrophy, Patterned, 3

Martinique Crinkled Retinal Pigment Epitheliopathy	Patterned Macular Dystrophy 3
MDPT3	Mcrpe

Periosteal Chondrosarcoma

Juxtacortical Chondrosarcoma

Mild Cognitive Impairment

Adolescence-Adult Electroclinical Syndrome

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Spondyloepiphyseal Dysplasia Congenita

SEDC	Sed Congenita
Spondyloepiphyseal Dysplasia, Congenital Type	Late Spondyloepiphyseal Dysplasia
Sed, Congenital Type	Congenital Spondyloepiphyseal Dysplasia
Spranger-Wiedemann Disease	Spondyloepiphyseal Dysplasia Congenital Type
Dysplasia, Spondyloepiphyseal, Congenita	Spondyloepiphyseal Dysplasia, Congenita
Spondyloepiphyseal Dysplasia Tarda, X-Linked

Heinz Body Anemias

Heinz Body Anemia	Heinz Body Anemias, Alpha-
HEIBAN	Anemia, Heinz Body
Acquired Heinz Body Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15920	YEATS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	YEATS2	VGNC	VGNC:48482
Macaca mulatta	YEATS2	VGNC	VGNC:79502
Mus musculus	YEATS2	MGD	MGI:2447762
Rattus norvegicus	YEATS2	RGD	RGD:1566176
Felis catus	YEATS2	VGNC	VGNC:67134
Bos taurus	YEATS2	VGNC	VGNC:37020

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