TENM3 - teneurin transmembrane protein 3 Gene

Homo sapiens

Also known as ODZ3; TEN3; TNM3; ten-3; Ten-m3; MCOPCB9; MCOPS15

Gene ID: 55714 | Gene type: protein coding

About TENM3

Cytogenetic location: 4q34.3-q35.1 Genomic coordinates (GRCh38): 4:181,447,613-182,803,024 (from NCBI)

This gene has 6 transcripts (splice variants), 327 orthologues, 4 paralogues and is associated with 3 phenotypes. Broad expression in placenta (RPKM 7.1), brain (RPKM 4.3) and 14 other tissues.

Summary

This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]

TENM3 Products(1)

mRNA	Protein	Name
NM_001080477.4	NP_001073946.1	teneurin-3

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	22766609	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TENM3 Protein Structure

Ten_N

Tox-GHH

0
500
1000
1500
2000
2500
2699 a.a.

Protein Preferred Names

Protein Names

teneurin-3

ODZ3-like protein

Related Diseases

Diseases

Alias

Microphthalmia, Isolated, With Coloboma 9

MCOPCB9	Microphthalmia, Syndromic 15
Microphthalmia, Isolated, With Coloboma, 9	Isolated Colobomatous Microphthalmia 9
Microphthalmia, Syndromic, 15	MCOPS15
Microphthalmia And/Or Coloboma With Developmental Delay	Microphthalmia, Isolated, With Coloboma, Type 9

Colobomatous Microphthalmia

Anophthalmia-Microphthalmia Syndrome	Mac
Microphthalmia With Colobomatous Cyst	Microphthalmia-Anophthalmia-Coloboma Syndrome
Microphthalmia-Anophthalmia-Coloboma	Microphthalmia And Mental Deficiency

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Sclerocornea

Isolated Congenital Sclerocornea

Spinocerebellar Ataxia, Autosomal Recessive 12

Autosomal Recessive Spinocerebellar Ataxia 12	SCAR12
Spinocerebellar Ataxia With Mental Retardation And Epilepsy	Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Wwox Deficiency
Autosomal Recessive Spinocerebellar Ataxia Type 12	Spinocerebellar Ataxia, Autosomal Recessive, 12
Ataxia, Spinocerebellar, Autosomal Recessive, Type 12

Anterior Segment Dysgenesis

Anterior Segment Developmental Anomaly	Anterior Segment Mesenchymal Dysgenesis
Corneal Opacification And Other Ocular Anomalies	Sclerocornea With Other Ocular Anomalies
Asmd	Asod
Anterior Segment Ocular Dysgenesis	Foxe3-Related Ocular Disorder
Familial Ocular Anterior Segment Mesenchymal Dysgenesis	Dysgenesis, Anterior Segment
Irido-Corneal Dysgenesis	Axenfeld-Rieger Syndrome, Type 3

Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type

Wilson-Turner Syndrome	WTS
Mrxs6	X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome
Mrxswt	Wilson-Turner X-Linked Mental Retardation Syndrome
Mental Retardation, X-Linked, Syndromic 6	Mental Retardation, X-Linked, With Gynecomastia And Obesity
Intellectual Disability, X-Linked, Syndromic 6	Intellectual Disability, X-Linked, With Gynecomastia And Obesity
Wilson Turner Intellectual Disability Syndrome	X-Linked Intellectual Disability - Gynecomastia - Obesity

Ptosis

Blepharoptosis	Drooping Eyelid
Droopy Eyelid	Ptosis Of Eyelid
Paralysis Of Levator Palpebrae Superioris

Syndromic X-Linked Intellectual Disability

X-Linked Syndromic Intellectual Disability

Coloboma Of Macula

Coloboma	Congenital Ocular Coloboma
Microphthalmia, Isolated, With Coloboma	Agenesis Of Macula
Hereditary Macular Coloboma	Ocular Coloboma
Coloboma Of Eye	Macular Coloboma
Uveoretinal Coloboma

Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14364	TENM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TENM3	MGD	MGI:1345183
Macaca mulatta	TENM3	VGNC	VGNC:100277
Felis catus	TENM3	VGNC	VGNC:66071
Rattus norvegicus	TENM3	RGD	RGD:1306641
Canis familiaris	TENM3	VGNC	VGNC:47248
Bos taurus	TENM3	VGNC	VGNC:35743

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