EDEM2 - ER degradation enhancing alpha-mannosidase like protein 2 Gene

Homo sapiens

Also known as C20orf31; C20orf49; bA4204.1

Gene ID: 55741 | Gene type: protein coding

About EDEM2

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,115,364-35,147,336 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 6 paralogues. Ubiquitous expression in placenta (RPKM 13.1), lung (RPKM 12.7) and 25 other tissues.

Summary

In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the Proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008]

EDEM2 Products(2)

mRNA	Protein	Name
NM_001145025.2	NP_001138497.1	ER degradation-enhancing alpha-mannosidase-like protein 2 isoform 2 precursor
NM_018217.3	NP_060687.2	ER degradation-enhancing alpha-mannosidase-like protein 2 isoform 1 precursor

EDEM2 Protein Structure

Glyco_hydro_47

0
100
200
300
400
500
578 a.a.

Protein Preferred Names

Protein Names

ER degradation-enhancing alpha-mannosidase-like protein 2

ER degradation enhancer, mannosidase alpha-like 2

Recombinant EDEM2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76897	EDEM2 Protein, Human (HEK293, His)	AAH01371.1 (A22-K492)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04158	EDEM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EDEM2	MGD	MGI:1915540
Bos taurus	EDEM2	VGNC	VGNC:28323
Canis familiaris	EDEM2	VGNC	VGNC:40195
Macaca mulatta	EDEM2	VGNC	VGNC:72050
Rattus norvegicus	EDEM2	RGD	RGD:1303074
Felis catus	EDEM2	VGNC	VGNC:61723
Others	EDEM2	NCBI

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