RIOK2 - RIO kinase 2 Gene

Homo sapiens

Also known as RIO2

Gene ID: 55781 | Gene type: protein coding

About RIOK2

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:97,160,867-97,183,247 (from NCBI)

This gene has 7 transcripts (splice variants), 198 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 5.0), ovary (RPKM 4.8) and 25 other tissues.

Summary

Predicted to enable protein kinase activity. Involved in several processes, including positive regulation of rRNA processing; positive regulation of ribosomal small subunit export from nucleus; and regulation of mitotic metaphase/anaphase transition. Located in cytoplasm. Part of preribosome, small subunit precursor. [provided by Alliance of Genome Resources, Apr 2022]

RIOK2 Products(2)

mRNA	Protein	Name
NM_001159749.2	NP_001153221.1	serine/threonine-protein kinase RIO2 isoform 2
NM_018343.3	NP_060813.2	serine/threonine-protein kinase RIO2 isoform 1

RIOK2 Protein Structure

Rio2_N

RIO1

0
100
200
300
400
500
552 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase RIO2

Related Diseases

Diseases

Alias

Cecum Carcinoma

Cecum Cancer	Caecum Carcinoma
Carcinoma Of Cecum	Cecal Cancer
Malignant Neoplasm Of Caecum	Malignant Tumor Of The Cecum

Cecum Adenocarcinoma

Cecal Adenocarcinoma

Adenocarcinoma Of Cecum

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147655	CQ211	Inhibitor	99.58%	Unkown
HY-156465	RIOK2-IN-2	Inhibitor	/	Unkown
HY-156792	RIOK2-IN-1		/	Unkown
HY-RS11989	RIOK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RIOK2	VGNC	VGNC:76774
Bos taurus	RIOK2	VGNC	VGNC:50056
Felis catus	RIOK2	VGNC	VGNC:97605
Mus musculus	RIOK2	MGD	MGI:1914295
Rattus norvegicus	RIOK2	RGD	RGD:1311588
Canis familiaris	RIOK2	VGNC	VGNC:53201
Others	RIOK2	NCBI

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