METTL2B - methyltransferase 2B, methylcytidine Gene

Homo sapiens

Also known as METL; METTL2; METTL2A; PSENIP1

Gene ID: 55798 | Gene type: protein coding

About METTL2B

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,476,748-128,506,602 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 7.8), fat (RPKM 7.8) and 25 other tissues.

Summary

This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

METTL2B Products(1)

mRNA	Protein	Name
NM_018396.3	NP_060866.2	tRNA N(3)-methylcytidine methyltransferase METTL2B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32427860	GOA
enables tRNA (cytidine) methyltransferase activity	IMP IMP: Inferred from mutant phenotype	21518805	GOA
enables tRNA (cytidine-3-)-methyltransferase activity	IMP IMP: Inferred from mutant phenotype	28655767	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in tRNA metabolic process	IMP IMP: Inferred from mutant phenotype	28655767	GOA
involved in tRNA methylation	IMP IMP: Inferred from mutant phenotype	21518805	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	34268557	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL2B Protein Structure

Methyltransf_23

0
100
200
300
378 a.a.

Protein Preferred Names

Protein Names

tRNA N(3)-methylcytidine methyltransferase METTL2B

methyltransferase like 2B

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08363	METTL2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	METTL2B	MGD	MGI:1289171

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