TRERF1 - transcriptional regulating factor 1 Gene

Homo sapiens

Also known as RAPA; BCAR2; TREP132; TReP-132; HSA277276; dJ139D8.5

Gene ID: 55809 | Gene type: protein coding

About TRERF1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,224,931-42,452,224 (from NCBI)

This gene has 8 transcripts (splice variants), 196 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 2.9), bone marrow (RPKM 2.6) and 24 other tissues.

Summary

This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

TRERF1 Products(5)

mRNA	Protein	Name
NM_001297573.2	NP_001284502.1	transcriptional-regulating factor 1 isoform 1
NM_001391983.1	NP_001378912.1	transcriptional-regulating factor 1 isoform 2
NM_001391984.1	NP_001378913.1	transcriptional-regulating factor 1 isoform 3
NM_001395490.1	NP_001382419.1	transcriptional-regulating factor 1 isoform 4
NM_033502.4	NP_277037.1	transcriptional-regulating factor 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear progesterone receptor binding	IPI IPI: Inferred from physical interaction	17015480	GOA
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	17015480	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11349124	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	11349124	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to progesterone stimulus	IDA IDA: Inferred from direct assay	17015480	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11349124	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17015480	GOA
involved in progesterone receptor signaling pathway	IDA IDA: Inferred from direct assay	17015480	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in nucleus	IDA IDA: Inferred from direct assay	11349124	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16371131	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRERF1 Protein Structure

zf-C2H2_6

ELM2

zf-C2H2_6

zf-C2H2_4

0
200
400
600
800
1000
1200 a.a.

Protein Preferred Names

Protein Names

transcriptional-regulating factor 1

breast cancer anti-estrogen resistance 2

Related Diseases

Diseases

Alias

Estrogen Resistance

Estrogen Resistance Syndrome	ESTRR
Estrogen Insensitivity

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15007	TRERF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRERF1	VGNC	VGNC:66521
Canis familiaris	TRERF1	VGNC	VGNC:47796
Rattus norvegicus	TRERF1	RGD	RGD:1307167
Macaca mulatta	TRERF1	VGNC	VGNC:79121
Bos taurus	TRERF1	VGNC	VGNC:36302
Mus musculus	TRERF1	MGD	MGI:2442086

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