WWC3 - WWC family member 3 Gene

Homo sapiens

Also known as BM042

Gene ID: 55841 | Gene type: protein coding

About WWC3

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:10,015,254-10,144,474 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 15.2), placenta (RPKM 10.3) and 25 other tissues.

Summary

This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]

WWC3 Products(1)

mRNA	Protein	Name
NM_015691.5	NP_056506.3	protein WWC3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	24682284	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	24682284	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	35429439	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hippo signaling	IDA IDA: Inferred from direct assay	35429439	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	24682284	GOA
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	24682284	GOA
involved in negative regulation of organ growth	IMP IMP: Inferred from mutant phenotype	24682284	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24682284	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	35429439	GOA
located in cytosol	IDA IDA: Inferred from direct assay	24682284	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein WWC3

Related Diseases

Diseases

Alias

Nivelon-Nivelon-Mabille Syndrome

Chondrodysplasia-Pseudohermaphroditism Syndrome	NNMS
Chondrodysplasia-Disorder Of Sex Development Syndrome	Nivelon Nivelon Mabille Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15858	WWC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	WWC3	VGNC	VGNC:48441
Bos taurus	WWC3	VGNC	VGNC:36976
Felis catus	WWC3	VGNC	VGNC:67098
Rattus norvegicus	WWC3	RGD	RGD:1560666
Macaca mulatta	WWC3	VGNC	VGNC:79790

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