GABRQ - gamma-aminobutyric acid type A receptor subunit theta Gene

Homo sapiens

Also known as THETA

Gene ID: 55879 | Gene type: protein coding

About GABRQ

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:152,637,895-152,658,965 (from NCBI)

This gene has 1 transcript (splice variant), 86 orthologues and 45 paralogues. Biased expression in brain (RPKM 1.4), adrenal (RPKM 0.9) and 4 other tissues.

Summary

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit Chloride Channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. [provided by RefSeq, Jul 2017]

GABRQ Products(1)

mRNA	Protein	Name
NM_018558.4	NP_061028.3	gamma-aminobutyric acid receptor subunit theta precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GABA-A receptor activity	IDA IDA: Inferred from direct assay	16412217	GOA
enables GABA-gated chloride ion channel activity	IDA IDA: Inferred from direct assay	16412217	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GABRQ Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
500
632 a.a.

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor subunit theta

GABA(A) receptor subunit theta

Related Diseases

Diseases

Alias

Essential Tremor

Benign Essential Tremor	Familial Tremor
Hereditary Essential Tremor	Essential Hereditary Tremor
Shaky Hand Syndrome	Benign Essential Tremor Syndrome
Tremor Hereditary Essential	Essential Tremor, Susceptibility To
Tremor, Hereditary Essential

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05224	GABRQ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GABRQ	MGD	MGI:1888498
Canis familiaris	GABRQ	VGNC	VGNC:41066
Rattus norvegicus	GABRQ	RGD	RGD:68331
Bos taurus	GABRQ	VGNC	VGNC:29202
Felis catus	GABRQ	VGNC	VGNC:62429

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