ZNF395 - zinc finger protein 395 Gene

Homo sapiens

Also known as PBF; PRF1; HDBP2; PRF-1; HDBP-2; HDRF-2; Si-1-8-14

Gene ID: 55893 | Gene type: protein coding

About ZNF395

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:28,345,590-28,386,460 (from NCBI)

This gene has 11 transcripts (splice variants), 257 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 29.1), placenta (RPKM 20.8) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

ZNF395 Products(1)

mRNA	Protein	Name
NM_018660.3	NP_061130.1	zinc finger protein 395

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14625278	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	28316371	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14625278	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	14625278	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11853404	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17531190	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	28316371	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14625278	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14625278	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger protein 395

HD gene regulatory region-binding protein 2

Related Diseases

Diseases

Alias

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16136	ZNF395 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ZNF395	VGNC	VGNC:48717
Bos taurus	ZNF395	VGNC	VGNC:37266
Macaca mulatta	ZNF395	VGNC	VGNC:104508
Mus musculus	ZNF395	MGD	MGI:2682318
Rattus norvegicus	ZNF395	RGD	RGD:1307849
Felis catus	ZNF395	VGNC	VGNC:67304

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