RCC2 - regulator of chromosome condensation 2 Gene

Homo sapiens

Also known as TD-60

Gene ID: 55920 | Gene type: protein coding

About RCC2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,406,760-17,439,677 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 214 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 29.5), skin (RPKM 28.3) and 25 other tissues.

Summary

The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal Cancer. [provided by RefSeq, Oct 2016]

RCC2 Products(2)

mRNA	Protein	Name
NM_001136204.3	NP_001129676.1	protein RCC2
NM_018715.4	NP_061185.1	protein RCC2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	12919680	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22282019	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	25074804	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25074804	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	12919680	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromosome passenger complex localization to kinetochore	IMP IMP: Inferred from mutant phenotype	12919680	GOA
involved in focal adhesion assembly	IDA IDA: Inferred from direct assay	19738201	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	19738201	GOA
involved in negative regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	25074804	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12919680	GOA
involved in positive regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	12919680	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, centromeric core domain	IDA IDA: Inferred from direct assay	12919680	GOA
colocalizes with membrane	IDA IDA: Inferred from direct assay	25074804	GOA
located in midbody	IDA IDA: Inferred from direct assay	12919680	GOA
located in mitotic spindle midzone	IDA IDA: Inferred from direct assay	12919680	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCC2 Protein Structure

RCC1

0
100
200
300
400
522 a.a.

Protein Preferred Names

Protein Names

protein RCC2

RCC1-like protein TD-60

Related Diseases

Diseases

Alias

Atrial Septal Defect 2

ASD2	Atrial Heart Septal Defect 2
Atrial Septal Defect-2	Asd Ii
Septal Defect, Atrial, Type 2

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139782	SKLB325		99.23%	Unkown
HY-RS11784	RCC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RCC2	VGNC	VGNC:33827
Macaca mulatta	RCC2	VGNC	VGNC:100054
Canis familiaris	RCC2	VGNC	VGNC:45441
Felis catus	RCC2	VGNC	VGNC:64546
Mus musculus	RCC2	MGD	MGI:1919784
Rattus norvegicus	RCC2	RGD	RGD:1309986

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