DMAP1 - DNA methyltransferase 1 associated protein 1 Gene

Homo sapiens

Also known as EAF2; SWC4; MEAF2; DNMAP1; DNMTAP1

Gene ID: 55929 | Gene type: protein coding

About DMAP1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:44,213,471-44,220,673 (from NCBI)

This gene has 15 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in adrenal (RPKM 14.7), ovary (RPKM 11.2) and 25 other tissues.

Summary

This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA Methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among Others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

DMAP1 Products(3)

mRNA	Protein	Name
NM_001034023.2	NP_001029195.1	DNA methyltransferase 1-associated protein 1
NM_001034024.2	NP_001029196.1	DNA methyltransferase 1-associated protein 1
NM_019100.5	NP_061973.1	DNA methyltransferase 1-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	15367675	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15367675	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15367675	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	27153538	GOA
involved in positive regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	15367675	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	27153538	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NuA4 histone acetyltransferase complex	IDA IDA: Inferred from direct assay	14966270	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15367675	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	27153538	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15367675	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DMAP1 Protein Structure

DMAP1

0
100
200
300
400
467 a.a.

Protein Preferred Names

Protein Names

DNA methyltransferase 1-associated protein 1

DNMT1 associated protein 1

DMAP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DMAP1	Q9NPF5	BFSP2	Homo sapiens	Q13515	Y2H Prey Pooling	32296183
Intra	DMAP1	Q9NPF5	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
Intra	DMAP1	Q9NPF5	MIS18A	Homo sapiens	Q9NYP9	Validated Y2H	32296183
Intra	DMAP1	Q9NPF5	NAP1L2	Homo sapiens	Q9ULW6	Validated Y2H	32296183
Intra	DMAP1	Q9NPF5	DAXX	Homo sapiens	Q9UER7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

DMAP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83253	DMAP1 Antibody (YA2998)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant

Autosomal Dominant Cerebellar Ataxia, Deafness And Narcolepsy	ADCADN
Autosomal Dominant Cerebellar Ataxia, Deafness, And Narcolepsy	Adca-Dn Syndrome
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome	Adca-Dn
Autosomal Dominant Cerebellar Ataxia-Hearing Loss-Narcolepsy Syndrome	Ataxia, Cerebellar, Deafness, And Narcolepsy, Autosomal Dominant

Atrophy Of Testis

Atrophic Testicle	Atrophy Of Testicle
Testicular Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03819	DMAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DMAP1	MGD	MGI:1913483
Rattus norvegicus	DMAP1	RGD	RGD:1311295
Canis familiaris	DMAP1	VGNC	VGNC:39995
Macaca mulatta	DMAP1	VGNC	VGNC:71857
Bos taurus	DMAP1	VGNC	VGNC:59178
Felis catus	DMAP1	VGNC	VGNC:61524

Name
Email *

	Sorry, but the email address you supplied was invalid.