GSDMC - gasdermin C Gene

Homo sapiens

Also known as MLZE

Gene ID: 56169 | Gene type: protein coding

About GSDMC

Cytogenetic location: 8q24.21 Genomic coordinates (GRCh38): 8:129,705,435-129,786,624 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 190 orthologues and 4 paralogues. Biased expression in skin (RPKM 9.5), spleen (RPKM 4.6) and 1 other tissue.

Summary

Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in defense response to bacterium and Pyroptosis. Predicted to act upstream of or within intestinal epithelial cell development. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

GSDMC Products(1)

mRNA	Protein	Name
NM_031415.3	NP_113603.1	gasdermin-C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables wide pore channel activity	IDA IDA: Inferred from direct assay	32929201	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	32929201	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11223543	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	32929201	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSDMC Protein Structure

Gasdermin

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

gasdermin-C

melanoma-derived leucine zipper, extra-nuclear factor

Recombinant GSDMC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71649	GSDMC Protein, Human (His-SUMO)	Q9BYG8 (M1-A508)	≥95%

Related Diseases

Diseases

Alias

Spinal Stenosis

Lumbar Spinal Stenosis	Cervical Spinal Stenosis
Spinal Stenosis Of Lumbar Region	Spinal Stenosis In Cervical Region
Spinal Canal Stenosis

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS05856	GSDMC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GSDMC	VGNC	VGNC:73380
Rattus norvegicus	GSDMC	RGD	RGD:1308989
Felis catus	GSDMC	VGNC	VGNC:68276
Canis familiaris	GSDMC	VGNC	VGNC:49925
Bos taurus	GSDMC	VGNC	VGNC:29674
Others	GSDMC	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.