PROC - protein C, inactivator of coagulation factors Va and VIIIa Gene

Homo sapiens

Also known as PC; APC; PROC1; THPH3; THPH4

Gene ID: 5624 | Gene type: protein coding

About PROC

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,418,427-127,429,242 (from NCBI)

This gene has 10 transcripts (splice variants), 102 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in liver (RPKM 55.9) and kidney (RPKM 6.8).

Summary

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine Protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]

PROC Products(12)

mRNA	Protein	Name
NM_000312.4	NP_000303.1	vitamin K-dependent protein C isoform 10 preproprotein
NM_001375602.1	NP_001362531.1	vitamin K-dependent protein C isoform 2
NM_001375603.1	NP_001362532.1	vitamin K-dependent protein C isoform 4 precursor
NM_001375604.1	NP_001362533.1	vitamin K-dependent protein C isoform 6 precursor
NM_001375605.1	NP_001362534.1	vitamin K-dependent protein C isoform 5 preproprotein
NM_001375606.1	NP_001362535.1	vitamin K-dependent protein C isoform 3 precursor
NM_001375607.1	NP_001362536.1	vitamin K-dependent protein C isoform 1
NM_001375608.1	NP_001362537.1	vitamin K-dependent protein C isoform 9 precursor
NM_001375609.1	NP_001362538.1	vitamin K-dependent protein C isoform 8
NM_001375610.1	NP_001362539.1	vitamin K-dependent protein C isoform 7 preproprotein
NM_001375611.1	NP_001362540.1	vitamin K-dependent protein C isoform 10 preproprotein
NM_001375613.1	NP_001362542.1	vitamin K-dependent protein C isoform 10 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15248212	GOA
enables serine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	25748729	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12563316	GOA
involved in negative regulation of coagulation	IMP IMP: Inferred from mutant phenotype	25651845	GOA
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	25651845	GOA
involved in positive regulation of establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	25651845	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	25748729	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	25748729	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROC Protein Structure

Gla

FXa_inhibition

Trypsin

0
100
200
300
400
461 a.a.

Protein Preferred Names

Protein Names

vitamin K-dependent protein C

Protein C-Nagoya

Recombinant PROC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74237	Coagulation Factor XIV/PROC Protein, Human (HEK293, His)	P04070 (T19-P461)	≥95%

Related Diseases

Diseases

Alias

Thrombophilia Due To Protein C Deficiency, Autosomal Recessive

THPH4	Autosomal Recessive Thrombophilia Due To Protein C Deficiency
Autosomal Recessive Protein C Deficiency	Autosomal Recessive Thrombophilia Due To Pc Deficiency
Autosomal Recessive Thrombophilia Due To Congenital Protein C Deficiency	Hereditary Thrombophilia Due To Congenital Protein C Deficiency
Severe Hereditary Thrombophilia Due To Congenital Protein C Deficiency	Protein C Deficiency, Autosomal Recessive
Proc Deficiency, Autosomal Recessive	Thrombophilia 3 Due To Protein C Deficiency, Autosomal Recessive
Autosomal Recessive Proc Deficiency	Autosomal Recessive Hereditary Thrombophilia Due To Protein C Deficiency
Hereditary Thrombophilia Due To Pc Deficiency	Proc Deficiency Autosomal Recessive
Protein C Deficiency Autosomal Recessive	Thrombophilia, Hereditary, Due To Protein C Deficiency, Autosomal Recessive

Thrombophilia Due To Protein C Deficiency, Autosomal Dominant

THPH3	Thrombophilia, Hereditary, Due To Protein C Deficiency, Autosomal Dominant
Protein C Deficiency, Autosomal Dominant	Proc Deficiency, Autosomal Dominant
Thrombophilia 3 Due To Protein C Deficiency, Autosomal Dominant	Autosomal Dominant Thrombophilia Due To Protein C Deficiency
Autosomal Dominant Proc Deficiency	Autosomal Dominant Protein C Deficiency
Proc Deficiency Autosomal Dominant	Protein C Deficiency Autosomal Dominant

Protein C Deficiency

Hereditary Thrombophilia Due To Protein C Deficiency	Proc Deficiency
Congenital Thrombotic Disease, Due To Protein C Deficiency

Purpura Fulminans

Purpura Gangrenosa

Purpura

Purpuric Disorder

Thrombophilia

Hypercoagulability State

Thrombosis

Thrombosis Of Blood Vessel

Thrombophilia Due To Thrombin Defect

Venous Thromboembolism	Venous Thrombosis
Thrombophilia Due To Factor 2 Defect	Thromboembolism
THPH1	Thromboembolism, Susceptibility To
Venous Thromboembolism, Susceptibility To	Venous Thrombosis, Protection Against
Prothrombin-Related Thrombophilia	Hyperprothrombinemia
Venous Thrombosis, Susceptibility To	Thrombophilia 1 Due To Thrombin Defect
F2-Related Thrombophilia	Factor Ii-Related Thrombophilia
Prothrombin 20210g>A Thrombophilia	Prothrombin G20210a Thrombophilia
Prothrombin Thrombophilia

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Inner Ear Cancer

Internal Auditory Canal Meningioma

Meningioma Of The Internal Auditory Canal

Protein S Deficiency

Protein S Deficiency Disease

Hereditary Thrombophilia Due To Protein S Deficiency

Thrombophlebitis

Phlebitis And Thrombophlebitis Of Superficial Vessels Of Lower Extremities	Superficial Thrombophlebitis Of Leg
Thrombophlebitis Of A Superficial Leg Vein	Thrombophlebitis Of Superficial Veins Of Lower Extremity

Pulmonary Embolism

Pulmonary Artery Embolism	Pulmonary Embolus
Pulmonary Emboli

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99229	Upifitamab		98.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11190	PROC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PROC	VGNC	VGNC:56139
Mus musculus	PROC	MGD	MGI:97771
Canis familiaris	PROC	VGNC	VGNC:45006
Rattus norvegicus	PROC	RGD	RGD:3411
Macaca fascicularis	PROC	NCBI	NCBI:102136210
Others	PROC	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.