IRGC - immunity related GTPase cinema Gene

Homo sapiens

Also known as IFGGE; IRGC1; Iigp5; CINEMA; R30953_1

Gene ID: 56269 | Gene type: protein coding

About IRGC

This gene has 2 transcripts (splice variants), 395 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 28.8).

Summary

Predicted to enable GTPase activity. Predicted to be involved in cellular response to interferon-beta and defense response. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

IRGC Products(1)

mRNA	Protein	Name
NM_019612.4	NP_062558.1	interferon-inducible GTPase 5

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in lipid droplet	IDA IDA: Inferred from direct assay	37195149	GOA
located in sperm flagellum	IDA IDA: Inferred from direct assay	37195149	GOA
located in sperm mitochondrial sheath	IDA IDA: Inferred from direct assay	37195149	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRGC Protein Structure

IIGP

0
100
200
300
400
463 a.a.

Protein Preferred Names

Protein Names

interferon-inducible GTPase 5

immunity-related GTPase cinema 1

IRGC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IRGC	Q6NXR0	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	IRGC	Q6NXR0	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	IRGC	Q6NXR0	CCNDBP1	Homo sapiens	O95273	Y2H Array	32296183
Intra	IRGC	Q6NXR0	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chronic Inflammatory Demyelinating Polyneuritis

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Japanese Spotted Fever

Oriental Spotted Fever

Rickettsia Japonica Spotted Fever

Ureterolithiasis

Calculus Of Ureter	Ureteric Stone
Ureteral Calculi	Ureteric Calculus
Stone In The Ureter	Ureter Calculi
Ureteral Calculus Or Stone	Ureterolith
Ureterolithiasis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06914	IRGC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IRGC	RGD	RGD:1311107
Bos taurus	IRGC	VGNC	VGNC:30281
Mus musculus	IRGC	MGD	MGI:2685948

Name
Email *

	Sorry, but the email address you supplied was invalid.