BEX4 - brain expressed X-linked 4 Gene

Homo sapiens

Also known as BEXL1

Gene ID: 56271 | Gene type: protein coding

About BEX4

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:103,215,092-103,217,246 (from NCBI)

This gene has 2 transcripts (splice variants) and 80 orthologues. Ubiquitous expression in brain (RPKM 111.7), thyroid (RPKM 67.9) and 23 other tissues.

Summary

This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the Other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]

BEX4 Products(2)

mRNA	Protein	Name
NM_001080425.4	NP_001073894.1	protein BEX4
NM_001127688.2	NP_001121160.1	protein BEX4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	27512957	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	27512957	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	27512957	GOA
involved in negative regulation of tubulin deacetylation	IMP IMP: Inferred from mutant phenotype	27512957	GOA
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	27512957	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	27512957	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27512957	GOA
located in microtubule	IDA IDA: Inferred from direct assay	27512957	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27512957	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	27512957	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BEX4 Protein Structure

BEX

0
100
120 a.a.

Protein Preferred Names

Protein Names

protein BEX4

BEX family member 4

Related Diseases

Diseases

Alias

Hypoglycemia, Leucine-Induced

Leucine-Sensitive Hypoglycemia Of Infancy	Leucine-Induced Hypoglycemia
LIH	Hypoglycemia Of Infancy, Leucine-Sensitive
Familial Infantile Hypoglycemia Precipitated By Leucine	Hypoglycemia Leucine Induced
Hypoglycemia Leucine-Induced

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01483	BEX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BEX4	MGD	MGI:3606746
Rattus norvegicus	BEX4	RGD	RGD:1564749

Name
Email *

	Sorry, but the email address you supplied was invalid.