2. Gene
  3. KLK7 - kallikrein related peptidase 7 Gene

KLK7 - kallikrein related peptidase 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as hK7; SCCE; PRSS6

Gene ID: 5650 | Gene type: protein coding

About KLK7

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:50,976,468-50,984,064 (from NCBI)

This gene has 6 transcripts (splice variants), 107 orthologues and 12 paralogues. Biased expression in skin (RPKM 68.1) and esophagus (RPKM 25.3).

Summary

This gene encodes a member of the Kallikrein subfamily of serine proteases. These Enzymes have diverse physiological functions and many Kallikrein genes are biomarkers for Cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in Cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of Cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen Kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]

KLK7 Products(4)

mRNA Protein Name
NM_001207053.2 NP_001193982.1 kallikrein-7 isoform 2
NM_001243126.1 NP_001230055.1 kallikrein-7 isoform 3
NM_005046.4 NP_005037.1 kallikrein-7 isoform 1 preproprotein
NM_139277.2 NP_644806.1 kallikrein-7 isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
17012259 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of antibacterial peptide production IMP
IMP: Inferred from mutant phenotype
17012259 GOA
Cellular Component GO Annotation Evidence Reference Source
located in epidermal lamellar body IDA
IDA: Inferred from direct assay
15675955 GOA
located in extracellular space IMP
IMP: Inferred from mutant phenotype
17012259 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLK7 Protein Structure

Trypsin

Trypsin: Trypsin (30 - 245)

  • 0
  • 100
  • 200
  • 253 a.a.
Protein Preferred Names Protein Names

kallikrein-7

kallikrein 7 (chymotryptic, stratum corneum)

Recombinant KLK7 Proteins

Cat. No. Product Name Accession Purity
HY-P70163 Kallikrein-7 Protein, Human (HEK293, His, solution) AAH32005 (E23-H252) ≥95%
HY-P76466 Kallikrein-7 Protein, Human (HEK293, His) NP_005037.1 (E23-R253) ≥95%

Related Diseases

Diseases Alias
Netherton Syndrome

NETH

Ns

Netherton Disease

Comel-Netherton Syndrome

Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige

Bamboo Hair Syndrome

Ichthyosis Linearis Circumflexa

Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige

Ilc

Nts

N Syndrome
Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis
Occupational Dermatitis

Dermatitis, Occupational

Occupational Allergic Contact Dermatitis

Occupational Eczema
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Psoriasis
Peeling Skin Syndrome

Deciduous Skin

Familial Continuous Skin Peeling Syndrome

Idiopathic Deciduous Skin

Keratosis Exfoliativa Congenita

Pss

Peeling Skin Disease

Skin Peeling Syndrome

Familial Continuous Skin Peeling

Keratolysis Exfoliativa Congenita

Exfoliation Syndrome

Keratolysis Exfoliativa
Ichthyosis Vulgaris

Ichthyosis Simplex

Dominant Congenital Ichthyosiform Erythroderma

Common Ichthyosis

Fish Scale Disease

VI

Ichthyoses

Congenital Ichthyosis
Ichthyosis, Congenital, Autosomal Recessive 4b

Harlequin Ichthyosis

Autosomal Recessive Congenital Ichthyosis 4b

Hi

Harlequin Fetus

ARCI4B

Ichthyosis Congenita, Harlequin Fetus Type

Harlequin Type Ichthyosis

'Harlequin Fetus'

Harlequin Type Ichthyosis Congenita

Harlequin Type Ichthyosis Fetalis

Harlequin Baby Syndrome

Ichthyosis Congenita, Harlequin Type

Ichthyosis Fetalis, Harlequin Type

Ichthyosis Congenita Harlequin Fetus Type

Ichthyosis, Harlequin

Ichthyosis, Congenital, Autosomal Recessive, Type 4b
Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma

Li

Congenital Nonbullous Ichthyosiform Erythroderma

Arci

Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma

Cie

Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis

Nbcie

Ncie

Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar

Nbie

Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P4669 LM-030 Inhibitor / Unkown
HY-RS07385 KLK7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KLK7 RGD RGD:1306420
Felis catus KLK7 VGNC VGNC:67967
Mus musculus KLK7 MGD MGI:1346336
Macaca mulatta KLK7 VGNC VGNC:74193
Bos taurus KLK7 VGNC VGNC:30681
Others KLK7 NCBI