TMPRSS15 - transmembrane serine protease 15 Gene

Homo sapiens

Also known as ENTK; PRSS7

Gene ID: 5651 | Gene type: protein coding

About TMPRSS15

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:18,269,116-18,460,676 (from NCBI)

This gene has 3 transcripts (splice variants), 146 orthologues, 17 paralogues and is associated with 2 phenotypes. Restricted expression toward duodenum (RPKM 404.7).

Summary

This gene encodes an Enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]

TMPRSS15 Products(1)

mRNA	Protein	Name
NM_002772.3	NP_002763.3	enteropeptidase precursor

TMPRSS15 Protein Structure

SEA

CUB

MAM

CUB

Ldl_recept_a

SRCR_2

Trypsin

0
200
400
600
800
1019 a.a.

Protein Preferred Names

Protein Names

enteropeptidase

enterokinase catalytic subunit

Related Diseases

Diseases

Alias

Enterokinase Deficiency

Enteropeptidase Deficiency	Congenital Enterokinase Deficiency
Congenital Enteropathy Due To Enteropeptidase Deficiency	Deficiency Of Enteropeptidase
ENTKD

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Acute Pancreatitis

Pancreatitis	Pancreatitis, Acute Necrotizing
Pancreatitis Nos	Acute Pancreas Inflammation

Pancreatitis

Mumps Pancreatitis

Noonan Syndrome 8

NS8	Noonan Syndrome, Type 8

Hymenolepiasis

Dwarf Tapeworm Infection	Hymenolepis Infectious Disease
Hymenolepsis Infection	Hyemolepis Nana Infection
Hymenolepiosis	Hymenolepis Infection
Dwarf Tapeworm	Hymenolepidosis
Hymenolepis Infestation

Pancreas Disease

Abnormality Of The Pancreas

Pancreatic Diseases

Ciliary Dyskinesia, Primary, 26

Primary Ciliary Dyskinesia 26	CILD26
Primary Ciliary Dyskinesia 26 With Or Without Situs Inversus	Ciliary Dyskinesia, Primary, 26, With Or Without Situs Inversus
Dyskinesia, Ciliary, Primary, 26

Developmental And Epileptic Encephalopathy 53

DEE53	Epileptic Encephalopathy, Early Infantile, 53
Eiee53	Developmental And Epileptic Encephalopathy, 53
Early Infantile Epileptic Encephalopathy 53

Acute Necrotizing Pancreatitis

Pancreatitis, Acute Necrotizing

Psoriasis 11

PSORS11	Psoriasis Susceptibility 11
Psoriasis	Psoriasis Vulgaris
Psoriasis 11, Susceptibility To	Pv

Acute Hemorrhagic Pancreatitis

Pancreatitis, Acute Hemorrhagic

Lactase Deficiency, Congenital

Congenital Lactase Deficiency	Disaccharide Intolerance Ii
Congenital Alactasia	Congenital Alactasia Syndrome
Congenital Lactose Intolerance	Congenital Lactose Malabsorption
Hereditary Alactasia	Alactasia, Congenital
Cld	COLACD
Disaccharide Intolerance Type 2	Cld - [Congenital Lactase Deficiency]
Disaccharide Intolerance 2	Lactose Intolerance Of Newborn
Hereditary Lactase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2990	Enteropeptidase		/	Unkown
HY-RS14768	TMPRSS15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TMPRSS15	VGNC	VGNC:36139
Canis familiaris	TMPRSS15	VGNC	VGNC:47632
Macaca mulatta	TMPRSS15	VGNC	VGNC:108449
Rattus norvegicus	TMPRSS15	RGD	RGD:1311046
Mus musculus	TMPRSS15	MGD	MGI:1197523
Felis catus	TMPRSS15	VGNC	VGNC:69091

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