MMP26 - matrix metallopeptidase 26 Gene

Homo sapiens

Gene ID: 56547 | Gene type: protein coding

About MMP26

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:4,704,784-4,992,429 (from NCBI)

This gene has 3 transcripts (splice variants), 513 orthologues and 23 paralogues. Restricted expression toward endometrium (RPKM 7.9).

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature Enzyme. This Enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016]

MMP26 Products(2)

mRNA	Protein	Name
NM_001384608.1	NP_001371537.1	matrix metalloproteinase-26 isoform 2
NM_021801.5	NP_068573.2	matrix metalloproteinase-26 isoform 1 preproprotein

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	23569462	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP26 Protein Structure

Peptidase_M10

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

matrix metalloproteinase-26

MMP-26

Recombinant MMP26 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76498	MMP-26 Protein, Human	Q9NRE1 (T90-P261)	≥95%

Related Diseases

Diseases

Alias

Endometrial Hyperplasia

Pyoderma Gangrenosum

Phagedenic Pyoderma

Phagedena Geometric

Pyoderma

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2682	MMP-8/MMP-26 Fluorogenic substrate		/	Unkown
HY-P3098	Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2		/	Unkown
HY-RS08545	MMP26 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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