Cript - CXXC repeat containing interactor of PDZ3 domain Gene

Rattus norvegicus

Gene ID: 56725 | Gene type: protein coding

About Cript

Summary

Enables PDZ domain binding activity and microtubule binding activity. Involved in several processes, including cytoplasmic microtubule organization; protein localization to microtubule; and regulation of postsynaptic density protein 95 clustering. Located in dendrite; neuronal cell body; and postsynaptic density. Orthologous to human CRIPT (CXXC repeat containing interactor of PDZ3 domain). [provided by Alliance of Genome Resources, Apr 2022]

Cript Products(1)

mRNA	Protein	Name
NM_019907.1	NP_063972.1	cysteine-rich PDZ-binding protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	9581762	RGD
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	10570482	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	9581762	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic microtubule organization	IDA IDA: Inferred from direct assay	9581762	RGD
involved in protein localization to microtubule	IMP IMP: Inferred from mutant phenotype	10570482	RGD
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	10570482	RGD
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	10570482	RGD
involved in regulation of postsynaptic density protein 95 clustering	IMP IMP: Inferred from mutant phenotype	10570482	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	9581762	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	9581762	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	9581762	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10570482	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	10570482	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	9581762	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	11160391	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cysteine-rich PDZ-binding protein

cysteine-rich interactor of PDZ three	cysteine-rich interactor of PDZ3
postsynaptic protein Cript

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03178	CRIPT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cript	NCBI	NCBI:9419
Macaca fascicularis	Cript	NCBI	NCBI:107126364
Mus musculus	Cript	NCBI	NCBI:56724
Leporidae	Cript	NCBI

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