IFNK - interferon kappa Gene

Homo sapiens

Also known as IFNT1; INFE1

Gene ID: 56832 | Gene type: protein coding

About IFNK

Cytogenetic location: 9p21.2 Genomic coordinates (GRCh38): 9:27,524,290-27,526,498 (from NCBI)

This gene has 1 transcript (splice variant), 141 orthologues and 16 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008]

IFNK Products(1)

mRNA	Protein	Name
NM_020124.3	NP_064509.2	interferon kappa precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables type I interferon receptor binding	IDA IDA: Inferred from direct assay	11514542	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	11514542	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11514542	GOA
involved in response to virus	IEP IEP: Inferred from expression pattern	11514542	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNK Protein Structure

Interferon

0
100
207 a.a.

Protein Preferred Names

Protein Names

interferon kappa

IFN-kappa

Related Diseases

Diseases

Alias

Danubian Endemic Familial Nephropathy

Balkan Nephropathy	Balkan Endemic Nephropathy
Nephropathia Epidemica	Defn
Ben	Aristolochic Acid Nephropathy
Aan	Endemic Nephropathy Balkan
Balkan Nephritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06590	IFNK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IFNK	VGNC	VGNC:62877
Canis familiaris	IFNK	VGNC	VGNC:51739
Rattus norvegicus	IFNK	RGD	RGD:1309045
Mus musculus	IFNK	MGD	MGI:2683287
Bos taurus	IFNK	VGNC	VGNC:30060

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