KCMF1 - potassium channel modulatory factor 1 Gene

Homo sapiens

Also known as FIGC; PCMF; ZZZ1; DEBT91

Gene ID: 56888 | Gene type: protein coding

About KCMF1

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:84,971,161-85,059,472 (from NCBI)

This gene has 4 transcripts (splice variants) and 231 orthologues. Ubiquitous expression in testis (RPKM 9.7), thyroid (RPKM 7.1) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase activity. Predicted to be involved in synaptic signaling. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

KCMF1 Products(1)

mRNA	Protein	Name
NM_020122.5	NP_064507.3	E3 ubiquitin-protein ligase KCMF1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	15581609	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of HRI-mediated signaling	IDA IDA: Inferred from direct assay	38297121	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	37891180	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	38297121	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	34893540	GOA
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	34893540	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	34893540	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	38297121	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCMF1 Protein Structure

zf-Di19

0
100
200
300
381 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase KCMF1

FGF-induced in gastric cancer

Related Diseases

Diseases

Alias

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07096	KCMF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KCMF1	RGD	RGD:1591490
Mus musculus	KCMF1	MGD	MGI:1921537
Bos taurus	KCMF1	VGNC	VGNC:30419
Macaca mulatta	KCMF1	VGNC	VGNC:73868
Canis familiaris	KCMF1	VGNC	VGNC:58310

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