BDH2 - 3-hydroxybutyrate dehydrogenase 2 Gene

Homo sapiens

Also known as DHRS6; EFA6R; SDR15C1; UCPA-OR; UNQ6308; PRO20933

Gene ID: 56898 | Gene type: protein coding

About BDH2

This gene has 9 transcripts (splice variants) and 201 orthologues. Broad expression in kidney (RPKM 50.7), duodenum (RPKM 25.0) and 23 other tissues.

Summary

Enables 3-hydroxybutyrate dehydrogenase activity and NAD binding activity. Involved in epithelial cell differentiation and fatty acid beta-oxidation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

BDH2 Products(1)

mRNA	Protein	Name
NM_020139.4	NP_064524.3	dehydrogenase/reductase SDR family member 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-hydroxybutyrate dehydrogenase activity	IDA IDA: Inferred from direct assay	16380372	GOA
enables NAD binding	IDA IDA: Inferred from direct assay	16380372	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in epithelial cell differentiation	IDA IDA: Inferred from direct assay	21492153	GOA
involved in fatty acid beta-oxidation	IDA IDA: Inferred from direct assay	16380372	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16380372	GOA
NOT located in mitochondrion	IDA IDA: Inferred from direct assay	16380372	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BDH2 Protein Structure

adh_short_C2

0
100
200
245 a.a.

Protein Preferred Names

Protein Names

dehydrogenase/reductase SDR family member 6

3-hydroxybutyrate dehydrogenase type 2

(R)-beta-hydroxybutyrate dehydrogenase

Recombinant BDH2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7659	BDH2 Protein, Human (His)	AAH01953.1 (M1-L245)	≥95%

Related Diseases

Diseases

Alias

Alpha-Methylacetoacetic Aciduria

Beta-Ketothiolase Deficiency	3-Ketothiolase Deficiency
3-Oxothiolase Deficiency	Mitochondrial Acetoacetyl-Coa Thiolase Deficiency
Alpha-Methylacetoaceticaciduria	Mat Deficiency
T2 Deficiency	2-Methyl-3-Hydroxybutyricacidemia
Beta Ketothiolase Deficiency	Pseudo-Zellweger Syndrome
2-Methyl-3-Hydroxybutyric Acidemia	3-Ktd Deficiency
Peroxisomal Thiolase Deficiency	2-Methylacetoacetyl-Coenzyme A Thiolase Deficiency
3-Alpha-Oxothiolase Deficiency	Methylacetoacetyl-Coenzyme A Thiolase Deficiency
Mitochondrial 2-Methylacetoacetyl-Coa Thiolase Deficiency - Potassium Stimulated	Β-Ketothiolase Deficiency
Alpha Methylacetoacetic Aciduria	Alpha-Methyl-Acetoacetyl-Coa Thiolase Deficiency
Mitochondrial Acetoacetyl-Coenzyme A Thiolase Deficiency	3KTD
Aciduria, Alpha-Methylacetoacetic	Deficiency Of Acetyl-Coa Acetyltransferase
Deficiency Of Acetyl-Coa Acyltransferase	Hepatic Methionine Adenosyltransferase Deficiency
Bifunctional Peroxisomal Enzyme Deficiency

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01453	BDH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BDH2	VGNC	VGNC:26458
Canis familiaris	BDH2	VGNC	VGNC:38423
Felis catus	BDH2	VGNC	VGNC:60097
Rattus norvegicus	BDH2	RGD	RGD:1309898
Mus musculus	BDH2	MGD	MGI:1917022
Macaca mulatta	BDH2	VGNC	VGNC:70161
Others	BDH2	NCBI

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