MEIS3 - Meis homeobox 3 Gene

Homo sapiens

Also known as MRG2

Gene ID: 56917 | Gene type: protein coding

About MEIS3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,403,124-47,422,233 (from NCBI)

This gene has 14 transcripts (splice variants), 192 orthologues and 12 paralogues. Biased expression in endometrium (RPKM 15.5), brain (RPKM 9.1) and 10 other tissues.

Summary

This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]

MEIS3 Products(4)

mRNA	Protein	Name
NM_001009813.3	NP_001009813.1	homeobox protein Meis3 isoform 2
NM_001301059.2	NP_001287988.1	homeobox protein Meis3 isoform 3
NM_001346148.2	NP_001333077.1	homeobox protein Meis3 isoform 4
NM_020160.3	NP_064545.1	homeobox protein Meis3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17178831	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEIS3 Protein Structure

Homeobox_KN

0
100
200
300
375 a.a.

Protein Preferred Names

Protein Names

homeobox protein Meis3

Meis1, myeloid ecotropic viral integration site 1 homolog 3

Related Diseases

Diseases

Alias

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08327	MEIS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MEIS3	RGD	RGD:1308532
Mus musculus	MEIS3	MGD	MGI:108519
Bos taurus	MEIS3	VGNC	VGNC:52205
Canis familiaris	MEIS3	VGNC	VGNC:53737

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