PMEPA1 - prostate transmembrane protein, androgen induced 1 Gene

Homo sapiens

Also known as STAG1; TMEPAI

Gene ID: 56937 | Gene type: protein coding

About PMEPA1

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:57,648,396-57,711,472 (from NCBI)

This gene has 8 transcripts (splice variants), 94 orthologues and 1 paralogue. Broad expression in prostate (RPKM 54.2), fat (RPKM 28.9) and 20 other tissues.

Summary

This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the Androgen Receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

PMEPA1 Products(5)

mRNA	Protein	Name
NM_001255976.2	NP_001242905.1	protein TMEPAI isoform d
NM_020182.5	NP_064567.2	protein TMEPAI isoform a
NM_199169.3	NP_954638.1	protein TMEPAI isoform b
NM_199170.3	NP_954639.1	protein TMEPAI isoform c precursor
NM_199171.3	NP_954640.1	protein TMEPAI isoform c precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables R-SMAD binding	IPI IPI: Inferred from physical interaction	20129061	GOA
enables WW domain binding	IPI IPI: Inferred from physical interaction	12907594	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24627487	GOA
enables protein sequestering activity	IDA IDA: Inferred from direct assay	20129061	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	24627487	GOA
involved in negative regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	20129061	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	24627487	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20129061	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	20129061	GOA
located in early endosome membrane	IDA IDA: Inferred from direct assay	24627487	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	20129061	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein TMEPAI

solid tumor-associated 1 protein

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10761	PMEPA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PMEPA1	RGD	RGD:1308255
Mus musculus	PMEPA1	MGD	MGI:1929600
Canis familiaris	PMEPA1	VGNC	VGNC:44731
Macaca mulatta	PMEPA1	VGNC	VGNC:76023
Bos taurus	PMEPA1	VGNC	VGNC:33070
Felis catus	PMEPA1	VGNC	VGNC:64255

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