NIT2 - nitrilase family member 2 Gene

Homo sapiens

Also known as HEL-S-8a

Gene ID: 56954 | Gene type: protein coding

About NIT2

Cytogenetic location: 3q12.2 Genomic coordinates (GRCh38): 3:100,334,757-100,361,635 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 49.7), liver (RPKM 37.5) and 25 other tissues.

Summary

Enables omega-amidase activity. Involved in asparagine metabolic process; glutamine metabolic process; and oxaloacetate metabolic process. Located in centrosome and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

NIT2 Products(1)

mRNA	Protein	Name
NM_020202.5	NP_064587.1	omega-amidase NIT2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables omega-amidase activity	IDA IDA: Inferred from direct assay	22674578	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in asparagine metabolic process	IDA IDA: Inferred from direct assay	22674578	GOA
involved in glutamine metabolic process	IDA IDA: Inferred from direct assay	22674578	GOA
involved in oxaloacetate metabolic process	IDA IDA: Inferred from direct assay	22674578	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NIT2 Protein Structure

CN_hydrolase

0
100
200
276 a.a.

Protein Preferred Names

Protein Names

omega-amidase NIT2

Nit protein 2

Related Diseases

Diseases

Alias

Histidinemia

Histidine Ammonia-Lyase Deficiency	Hal Deficiency
Histidase Deficiency	His Deficiency
Histidinuria	Hyperhistidinemia
HISTID	Histidinuria Renal Tubular Defect

Atrial Septal Defect 4

ASD4	Atrial Heart Septal Defect 4
Septal Defect, Atrial, Type 4

Histidine Metabolism Disease

Disturbances Of Histidine Metabolism	Disorder Of Histidine Metabolism
Disturbance Of Histidine Metabolism

Alkaptonuria

Homogentisic Acid Oxidase Deficiency	Alcaptonuria
AKU	Deficiency Of Homogentisicase
Homogentisate 1,2-Dioxygenase Deficiency	Alkaptonuric Ochronosis
Homogentisic Acidura	Ochronosis, Hereditary
Hereditary Ochronosis	Ochronosis
Homogentisicaciduria	Deficiency Of Homogentisate Oxygenase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09311	NIT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NIT2	MGD	MGI:1261838
Felis catus	NIT2	VGNC	VGNC:102789
Canis familiaris	NIT2	VGNC	VGNC:43823
Macaca mulatta	NIT2	VGNC	VGNC:75281
Bos taurus	NIT2	VGNC	VGNC:32090
Rattus norvegicus	NIT2	RGD	RGD:1310494
Others	NIT2	NCBI

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