LHX9 - LIM homeobox 9 Gene

Homo sapiens

Gene ID: 56956 | Gene type: protein coding

About LHX9

Cytogenetic location: 1q31.3 Genomic coordinates (GRCh38): 1:197,912,464-197,935,478 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 20 paralogues. Biased expression in ovary (RPKM 2.6), testis (RPKM 0.9) and 1 other tissue.

Summary

This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

LHX9 Products(4)

mRNA	Protein	Name
NM_001014434.2	NP_001014434.1	LIM/homeobox protein Lhx9 isoform 2
NM_001370213.1	NP_001357142.1	LIM/homeobox protein Lhx9 isoform 3
NM_001410927.1	NP_001397856.1	LIM/homeobox protein Lhx9 isoform 4
NM_020204.3	NP_064589.2	LIM/homeobox protein Lhx9 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHX9 Protein Structure

LIM

Homeobox

0
100
200
300
397 a.a.

Protein Preferred Names

Protein Names

LIM/homeobox protein Lhx9

LIM homeobox protein 9

LHX9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LHX9	Q9NQ69	KHK	Homo sapiens	P50053	Y2H Array	25416956
Intra	LHX9	Q9NQ69	KHK	Homo sapiens	P50053	Y2H Prey Pooling	25416956
Intra	LHX9	Q9NQ69	CWF19L2	Homo sapiens	Q2TBE0	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gonadal Agenesis

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07638	LHX9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LHX9	MGD	MGI:1316721
Canis familiaris	LHX9	VGNC	VGNC:42669
Rattus norvegicus	LHX9	RGD	RGD:727956
Macaca mulatta	LHX9	VGNC	VGNC:74044
Bos taurus	LHX9	VGNC	VGNC:30878
Felis catus	LHX9	VGNC	VGNC:63226

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