SHD - Src homology 2 domain containing transforming protein D Gene

Homo sapiens

Gene ID: 56961 | Gene type: protein coding

About SHD

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,279,069-4,290,722 (from NCBI)

This gene has 5 transcripts (splice variants), 269 orthologues and 3 paralogues. Biased expression in brain (RPKM 6.5), heart (RPKM 2.0) and 5 other tissues.

Summary

Predicted to enable phosphotyrosine residue binding activity. [provided by Alliance of Genome Resources, Apr 2022]

SHD Products(2)

mRNA	Protein	Name
NM_001372011.1	NP_001358940.1	SH2 domain-containing adapter protein D
NM_020209.4	NP_064594.3	SH2 domain-containing adapter protein D

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24728074	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHD Protein Structure

SH2

0
100
200
300
340 a.a.

Protein Preferred Names

Protein Names

SH2 domain-containing adapter protein D

src homology 2 domain-containing transforming protein D

SHD Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SHD	Q96IW2	MET	Homo sapiens	P08581	FPS	24728074

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fetal Encasement Syndrome

Cocoon Syndrome	COCOS
Fetal Diseases

Branched-Chain Keto Acid Dehydrogenase Kinase Deficiency

BCKDKD	Branched-Chain Ketoacid Dehydrogenase Kinase Deficiency
Bckdk Deficiency	Autism-Epilepsy Syndrome Due To Branched Chain Ketoacid Dehydrogenase Kinase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12861	SHD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SHD	VGNC	VGNC:34594
Rattus norvegicus	SHD	RGD	RGD:1590885
Mus musculus	SHD	MGD	MGI:1099461
Felis catus	SHD	VGNC	VGNC:65121
Macaca mulatta	SHD	VGNC	VGNC:77353
Canis familiaris	SHD	VGNC	VGNC:46145

Name
Email *

	Sorry, but the email address you supplied was invalid.