CASS4 - Cas scaffold protein family member 4 Gene

Homo sapiens

Also known as CAS4; HEFL; HEPL; C20orf32

Gene ID: 57091 | Gene type: protein coding

About CASS4

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:56,412,036-56,460,382 (from NCBI)

This gene has 5 transcripts (splice variants), 191 orthologues and 3 paralogues. Broad expression in lung (RPKM 5.8), appendix (RPKM 4.9) and 15 other tissues.

Summary

Enables protein tyrosine kinase binding activity. Involved in several processes, including positive regulation of protein kinase B signaling; positive regulation of protein tyrosine kinase activity; and positive regulation of substrate adhesion-dependent cell spreading. Located in focal adhesion. Part of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CASS4 Products(4)

mRNA	Protein	Name
NM_001164114.2	NP_001157586.1	cas scaffolding protein family member 4 isoform b
NM_001164115.2	NP_001157587.1	cas scaffolding protein family member 4 isoform c
NM_001164116.2	NP_001157588.1	cas scaffolding protein family member 4 isoform a
NM_020356.4	NP_065089.2	cas scaffolding protein family member 4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	18256281	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	18256281	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	27677288	GOA
involved in positive regulation of protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	18256281	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	18256281	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23001926	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	27677288	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	18256281	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASS4 Protein Structure

SH3_9

Serine_rich

DUF3513

0
200
400
600
786 a.a.

Protein Preferred Names

Protein Names

cas scaffolding protein family member 4

HEF-like protein

Related Diseases

Diseases

Alias

Astigmatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01977	CASS4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CASS4	VGNC	VGNC:38741
Rattus norvegicus	CASS4	RGD	RGD:1310643
Bos taurus	CASS4	VGNC	VGNC:26789
Mus musculus	CASS4	MGD	MGI:2444482
Felis catus	CASS4	VGNC	VGNC:60389
Macaca mulatta	CASS4	VGNC	VGNC:70562

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