2. Gene
  3. CASS4 - Cas scaffold protein family member 4 Gene

CASS4 - Cas scaffold protein family member 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAS4; HEFL; HEPL; C20orf32

Gene ID: 57091 | Gene type: protein coding

About CASS4

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:56,412,036-56,460,382 (from NCBI)

This gene has 5 transcripts (splice variants), 191 orthologues and 3 paralogues. Broad expression in lung (RPKM 5.8), appendix (RPKM 4.9) and 15 other tissues.

Summary

Enables protein tyrosine kinase binding activity. Involved in several processes, including positive regulation of protein kinase B signaling; positive regulation of protein tyrosine kinase activity; and positive regulation of substrate adhesion-dependent cell spreading. Located in focal adhesion. Part of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CASS4 Products(4)

mRNA Protein Name
NM_001164114.2 NP_001157586.1 cas scaffolding protein family member 4 isoform b
NM_001164115.2 NP_001157587.1 cas scaffolding protein family member 4 isoform c
NM_001164116.2 NP_001157588.1 cas scaffolding protein family member 4 isoform a
NM_020356.4 NP_065089.2 cas scaffolding protein family member 4 isoform a

CASS4 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (18 - 66)

Serine_rich

Serine_rich: Serine rich protein interaction domain (435 - 593)

DUF3513

DUF3513: Domain of unknown function (DUF3513) (597 - 785)

  • 0
  • 200
  • 400
  • 600
  • 786 a.a.
Protein Preferred Names Protein Names

cas scaffolding protein family member 4

HEF-like protein

Related Diseases

Diseases Alias
Astigmatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01977 CASS4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CASS4 VGNC VGNC:38741
Rattus norvegicus CASS4 RGD RGD:1310643
Bos taurus CASS4 VGNC VGNC:26789
Mus musculus CASS4 MGD MGI:2444482
Felis catus CASS4 VGNC VGNC:60389
Macaca mulatta CASS4 VGNC VGNC:70562