PLAAT1 - phospholipase A and acyltransferase 1 Gene

Homo sapiens

Also known as A-C1; HRSL1; HSD28; HRASLS; HRASLS1; PLA/AT1; PLAAT-1; H-REV107

Gene ID: 57110 | Gene type: protein coding

About PLAAT1

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:193,240,606-193,281,426 (from NCBI)

This gene has 3 transcripts (splice variants), 273 orthologues and 7 paralogues. Biased expression in testis (RPKM 17.3), thyroid (RPKM 1.8) and 3 other tissues.

Summary

Enables Acyltransferase activity, transferring groups Other than amino-acyl groups and Phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process and phosphatidylcholine metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PLAAT1 Products(2)

mRNA	Protein	Name
NM_001366112.1	NP_001353041.1	phospholipase A and acyltransferase 1
NM_020386.5	NP_065119.3	phospholipase A and acyltransferase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables N-acyltransferase activity	IDA IDA: Inferred from direct assay	21880860	GOA
enables O-acyltransferase activity	IDA IDA: Inferred from direct assay	21880860	GOA
enables phospholipase A1 activity	IDA IDA: Inferred from direct assay	21880860	GOA
enables phospholipase A2 activity	IDA IDA: Inferred from direct assay	21880860	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-acylphosphatidylethanolamine metabolic process	IDA IDA: Inferred from direct assay	22825852	GOA
involved in phosphatidylcholine metabolic process	IDA IDA: Inferred from direct assay	21880860	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27623847	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27623847	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAAT1 Protein Structure

LRAT

0
100
168 a.a.

Protein Preferred Names

Protein Names

phospholipase A and acyltransferase 1

H-REV107 protein-related protein

PLAAT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLAAT1	Q9HDD0	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	PLAAT1	Q9HDD0	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	PLAAT1	Q9HDD0	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bothnia Retinal Dystrophy

Vasterbotten Dystrophy	BRD
Dystrophy, Retinal, Bothnia

Poland Syndrome

Poland Anomaly	Poland Sequence
Poland Syndactyly	Poland'S Syndrome
Poland'S Anomaly	Poland'S Syndactyly
Acro-Pectoro-Renal Field Defect	Brachydactyly, Absent Pectoral Muscles And Agenesis/Hypoplasia Of Kidneys
Unilateral Defect Of Pectoralis Muscle And Syndactyly Of The Hand	Unilateral Defect Of Pectoralis Major And Syndactyly Of The Hand

Microphthalmia, Syndromic 9

Matthew-Wood Syndrome	Spear Syndrome
Anophthalmia/Microphthalmia And Pulmonary Hypoplasia	Microphthalmia, Isolated, With Coloboma 8
MCOPS9	Anophthalmia, Clinical, With Mild Facial Dysmorphism And Variable Malformations Of The Lung, Heart, And Diaphragm
Pulmonary Hypoplasia-Diaphragmatic Hernia-Anophthalmia-Cardiac Defect	Pdac
Pulmonary Agenesis, Microphthalmia, And Diaphragmatic Defect	Pmd
Syndromic Microphthalmia 9	Anophthalmia-Pulmonary Hypoplasia Syndrome
Clinical Anophthalmia Mild Facial Dysmorphism Lung Heart And Diaphragm Malformations	Pulmonary Agenesis Microphthalmi And Diaphragmatic Defect
Microphthalmia Syndromic 9	Matthew Wood Syndrome
Pdac Syndrome	Pulmonary Hypoplasia-Diaphragmatic Hernia-Anophthalmia-Cardiac Defect Syndrome
Microphthalmia, Isolated, With Coloboma, 8	MCOPCB8
Isolated Colobomatous Microphthalmia 8	Microphthalmia, Syndromic, 9
Anophthalmia With Pulmonary Hypoplasia	Microphthalmia Syndromic, Type 9
Anophthalmia And Pulmonary Hypoplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10637	PLAAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PLAAT1	VGNC	VGNC:102805
Bos taurus	PLAAT1	VGNC	VGNC:53580
Macaca mulatta	PLAAT1	VGNC	VGNC:76029
Canis familiaris	PLAAT1	VGNC	VGNC:41782
Rattus norvegicus	PLAAT1	RGD	RGD:1309485
Mus musculus	PLAAT1	MGD	MGI:1351473

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