RHBG - Rh family B glycoprotein Gene

Homo sapiens

Also known as SLC42A2

Gene ID: 57127 | Gene type: protein coding

About RHBG

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,366,046-156,385,219 (from NCBI)

This gene has 9 transcripts (splice variants), 210 orthologues and 4 paralogues. Biased expression in kidney (RPKM 4.7), ovary (RPKM 3.9) and 5 other tissues.

Summary

This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

RHBG Products(6)

mRNA	Protein	Name
NM_001256395.2	NP_001243324.1	ammonium transporter Rh type B isoform b
NM_001256396.2	NP_001243325.1	ammonium transporter Rh type B isoform c
NM_001412175.1	NP_001399104.1	ammonium transporter Rh type B isoform d precursor
NM_001412176.1	NP_001399105.1	ammonium transporter Rh type B isoform e
NM_001412177.1	NP_001399106.1	ammonium transporter Rh type B isoform f
NM_020407.5	NP_065140.3	ammonium transporter Rh type B isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ammonium channel activity	IDA IDA: Inferred from direct assay	15929723	GOA
enables ankyrin binding	IPI IPI: Inferred from physical interaction	15611082	GOA
enables carbon dioxide transmembrane transporter activity	IDA IDA: Inferred from direct assay	24077989	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ammonium transmembrane transport	IDA IDA: Inferred from direct assay	15929723	GOA
involved in transepithelial ammonium transport	IDA IDA: Inferred from direct assay	18032481	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	15611082	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11024028	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	15611082	GOA
located in spectrin-associated cytoskeleton	IMP IMP: Inferred from mutant phenotype	18635543	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHBG Protein Structure

Ammonium_transp

0
100
200
300
400
441 a.a.

Protein Preferred Names

Protein Names

ammonium transporter Rh type B

Rhesus blood group, B glycoprotein

Related Diseases

Diseases

Alias

Hemolytic Disease Of Fetus And Newborn, Rh-Induced

Rh Deficiency Syndrome	Rh Disease
HDFNRH	Rh Fetomaternal Incompatibility
Rh-Null Syndrome

Pseudohypoaldosteronism, Type I, Autosomal Recessive

Autosomal Recessive Pseudohypoaldosteronism Type 1	PHA1B
Pseudohypoaldosteronism Type 1	Pseudohypoaldosteronism, Type I
Generalized Pha1	Generalized Pseudohypoaldosteronism Type 1
Pseudohypoaldosteronism Type 1 Autosomal Recessive	Pha1
Pseudohypoaldosteronism	Pha I, Autosomal Recessive
Autosomal Recessive Pha 1	Pseudohypoaldosteronism Type 1, Recessive
Pseudohypoaldosteronism Type I	Autosomal Recessive Pha1
Pha Type 1	Pseudohypoaldosteronism 1, Autosomal Recessive
Multisystem Pseudohypoaldosteronism	Pha Type I, Autosomal Recessive
Pseudohypoaldosteronism Type I, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11938	RHBG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RHBG	VGNC	VGNC:55671
Rattus norvegicus	RHBG	RGD	RGD:727813
Mus musculus	RHBG	MGD	MGI:1927379
Felis catus	RHBG	VGNC	VGNC:99809
Macaca mulatta	RHBG	VGNC	VGNC:99814

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