SLC44A2 - solute carrier family 44 member 2 Gene

Homo sapiens

Also known as CTL2; PP1292

Gene ID: 57153 | Gene type: protein coding

About SLC44A2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,602,455-10,644,557 (from NCBI)

This gene has 15 transcripts (splice variants), 273 orthologues and 4 paralogues. Ubiquitous expression in placenta (RPKM 82.0), spleen (RPKM 69.3) and 25 other tissues.

Summary

Enables choline transmembrane transporter activity. Involved in choline transport and transmembrane transport. Located in mitochondrion and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC44A2 Products(3)

mRNA	Protein	Name
NM_001145056.2	NP_001138528.1	choline transporter-like protein 2 isoform 2
NM_001363611.2	NP_001350540.1	choline transporter-like protein 2 isoform 3
NM_020428.4	NP_065161.3	choline transporter-like protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables choline transmembrane transporter activity	IDA IDA: Inferred from direct assay	10677542	GOA
enables choline transmembrane transporter activity	IDA IDA: Inferred from direct assay	20410607	GOA
enables ethanolamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	33789160	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in choline transport	IDA IDA: Inferred from direct assay	10677542	GOA
involved in choline transport	IDA IDA: Inferred from direct assay	20410607	GOA
involved in ethanolamine transport	IDA IDA: Inferred from direct assay	33789160	GOA
involved in transmembrane transport	IDA IDA: Inferred from direct assay	20410607	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	33789160	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	26746385	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	26746385	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC44A2 Protein Structure

Choline_transpo

0
200
400
600
706 a.a.

Protein Preferred Names

Protein Names

choline transporter-like protein 2

solute carrier family 44 (choline transporter), member 2

Related Diseases

Diseases

Alias

Femoral Vein Thrombophlebitis

Phlebitis And Thrombophlebitis Of Femoral Vein	Thrombophlebitis Of The Femoral Vein
Thrombophlebitis Of Deep Femoral Vein

Choline Deficiency Disease

Choline Deficiency

Peripheral Vertigo

Vertigo, Peripheral

Meniere Disease

Meniere'S Disease	Otogenic Vertigo
Ménière Disease	Ménière'S Disease
Mnire'S Vertigo	Auditory Vertigo
Aural Vertigo	Meniere'S Syndrome
Ménière'S Vertigo	Primary Endolymphatic Hydrops
Menieres Disease	Vertigo, Aural
Labyrinth Hydrops	Labyrinthine Hydrops
Labyrinthine Vertigo	Ménière Syndrome
Ménière Vertigo	Idiopathic Endolymphatic Hydrops

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13252	SLC44A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC44A2	RGD	RGD:1309680
Bos taurus	SLC44A2	VGNC	VGNC:34876
Canis familiaris	SLC44A2	VGNC	VGNC:46418
Macaca mulatta	SLC44A2	VGNC	VGNC:77498
Mus musculus	SLC44A2	MGD	MGI:1915932
Felis catus	SLC44A2	VGNC	VGNC:65372

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