ZMIZ1 - zinc finger MIZ-type containing 1 Gene

Homo sapiens

Also known as MIZ; RAI17; ZIMP10; NEDDFSA; TRAFIP10

Gene ID: 57178 | Gene type: protein coding

About ZMIZ1

Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:79,068,966-79,316,519 (from NCBI)

This gene has 3 transcripts (splice variants), 265 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 21.7), spleen (RPKM 21.6) and 25 other tissues.

Summary

This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the Androgen Receptor, SMAD3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]

ZMIZ1 Products(1)

mRNA	Protein	Name
NM_020338.4	NP_065071.1	zinc finger MIZ domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SMAD binding	IPI IPI: Inferred from physical interaction	16777850	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	14609956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	16777850	GOA
involved in androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	14609956	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14609956	GOA
involved in pyramidal neuron migration to cerebral cortex	IMP IMP: Inferred from mutant phenotype	30639322	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	16777850	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14609956	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	14609956	GOA
located in nucleus	IDA IDA: Inferred from direct assay	30639322	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMIZ1 Protein Structure

zf-MIZ

0
200
400
600
800
1000
1067 a.a.

Protein Preferred Names

Protein Names

zinc finger MIZ domain-containing protein 1

retinoic acid induced 17

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Dysmorphic Facies And Distal Skeletal Anomalies

NEDDFSA

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Inflammatory Bowel Disease 24

IBD24

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16087	ZMIZ1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZMIZ1	MGD	MGI:3040693
Bos taurus	ZMIZ1	VGNC	VGNC:37195
Macaca mulatta	ZMIZ1	VGNC	VGNC:79036
Rattus norvegicus	ZMIZ1	RGD	RGD:1311620
Canis familiaris	ZMIZ1	VGNC	VGNC:48643

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