ACTR3B - actin related protein 3B Gene

Homo sapiens

Also known as ARP11; ARP3BETA

Gene ID: 57180 | Gene type: protein coding

About ACTR3B

This gene has 5 transcripts (splice variants), 184 orthologues and 26 paralogues. Broad expression in brain (RPKM 3.7), testis (RPKM 1.9) and 25 other tissues.

Summary

This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin Cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

ACTR3B Products(9)

mRNA	Protein	Name
NM_001040135.3	NP_001035225.1	actin-related protein 3B isoform 2
NM_001350940.2	NP_001337869.1	actin-related protein 3B isoform 3
NM_001350941.2	NP_001337870.1	actin-related protein 3B isoform 3
NM_001350942.2	NP_001337871.1	actin-related protein 3B isoform 3
NM_001350943.2	NP_001337872.1	actin-related protein 3B isoform 3
NM_001350944.2	NP_001337873.1	actin-related protein 3B isoform 4
NM_001350945.2	NP_001337874.1	actin-related protein 3B isoform 5
NM_001350946.2	NP_001337875.1	actin-related protein 3B isoform 6
NM_020445.6	NP_065178.1	actin-related protein 3B isoform 1

ACTR3B Protein Structure

Actin

0
100
200
300
418 a.a.

Protein Preferred Names

Protein Names

actin-related protein 3B

ARP3 actin related protein 3 homolog B

Related Diseases

Diseases

Alias

Breast Osteosarcoma

Osteogenic Sarcoma Of Breast

Breast Extraskeletal Osteosarcoma

Neuronopathy, Distal Hereditary Motor, Type I

Dhmn1	Hmn I
Distal Hereditary Motor Neuronopathy Type 1	Autosomal Dominant Distal Juvenile Spinal Muscular Atrophy Type 1
Neuronopathy, Distal Hereditary Motor, Type 1	HMN1
Neuropathy, Distal Hereditary Motor, Type I	Spinal Muscular Atrophy, Distal, Juvenile, Autosomal Dominant, I
Charcot-Marie-Tooth Disease, Spinal, I	Distal Hereditary Motor Neuropathy Type I
Spinal Charcot-Marie-Tooth Disease 1	Distal Hereditary Motor Neuropathy Type 1
Neuropathy, Motor, Distal, Hereditary, Type I

Lissencephaly 3

LIS3	Lissencephaly Due To Tuba1a Mutation
Lissencephaly Type 3	Lissencephaly, Type 3

Brachydactyly, Type A3

Brachydactyly Type A3	BDA3
Brachydactyly-Clinodactyly	Brachymesophalangy V
Brachymesophalangy 5	Brachydactyly Clinodactyly

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00232	ACTR3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ACTR3B	VGNC	VGNC:80326
Rattus norvegicus	ACTR3B	RGD	RGD:1565759
Mus musculus	ACTR3B	MGD	MGI:2661120
Bos taurus	ACTR3B	VGNC	VGNC:107215
Canis familiaris	ACTR3B	VGNC	VGNC:49707

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