CEMIP - cell migration inducing hyaluronidase 1 Gene

Homo sapiens

Also known as CCSP1; HYBID; TMEM2L; KIAA1199

Gene ID: 57214 | Gene type: protein coding

About CEMIP

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:80,779,370-80,951,771 (from NCBI)

This gene has 6 transcripts (splice variants), 198 orthologues and 1 paralogue. Biased expression in endometrium (RPKM 32.4), appendix (RPKM 6.2) and 5 other tissues.

Summary

Enables several functions, including clathrin heavy chain binding activity; hyaluronic acid binding activity; and hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process; positive regulation of protein phosphorylation; and positive regulation of transport. Located in clathrin-coated endocytic vesicle; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CEMIP Products(3)

mRNA	Protein	Name
NM_001293298.2	NP_001280227.1	cell migration-inducing and hyaluronan-binding protein precursor
NM_001293304.2	NP_001280233.1	cell migration-inducing and hyaluronan-binding protein precursor
NM_018689.3	NP_061159.1	cell migration-inducing and hyaluronan-binding protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ER retention sequence binding	IDA IDA: Inferred from direct assay	23990668	GOA
enables clathrin heavy chain binding	IDA IDA: Inferred from direct assay	23509262	GOA
enables hyaluronic acid binding	IDA IDA: Inferred from direct assay	23509262	GOA
enables hyalurononglucosaminidase activity	IMP IMP: Inferred from mutant phenotype	23509262	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23990668	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hyaluronan catabolic process	IMP IMP: Inferred from mutant phenotype	23509262	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	23990668	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	23990668	GOA
involved in positive regulation of protein kinase C activity	IDA IDA: Inferred from direct assay	23990668	GOA
involved in positive regulation of protein targeting to membrane	IDA IDA: Inferred from direct assay	23990668	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	23990668	GOA
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	14577002	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in clathrin-coated endocytic vesicle	IDA IDA: Inferred from direct assay	23509262	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16157444	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	14577002	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23990668	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23509262	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEMIP Protein Structure

Mucin2_WxxW

0
300
600
900
1200
1361 a.a.

Protein Preferred Names

Protein Names

cell migration-inducing and hyaluronan-binding protein

cell migration inducing hyaluronan binding protein

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02468	CEMIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02469	CEMIP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CEMIP	VGNC	VGNC:39099
Macaca mulatta	CEMIP	VGNC	VGNC:71130
Felis catus	CEMIP	VGNC	VGNC:60750
Bos taurus	CEMIP	VGNC	VGNC:27172
Mus musculus	CEMIP	MGD	MGI:2443629
Rattus norvegicus	CEMIP	RGD	RGD:1305254

Name
Email *

	Sorry, but the email address you supplied was invalid.