PTGER2 - prostaglandin E receptor 2 Gene

Homo sapiens

Also known as EP2

Gene ID: 5732 | Gene type: protein coding

About PTGER2

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:52,314,312-52,328,598 (from NCBI)

This gene has 2 transcripts (splice variants), 245 orthologues, 7 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 14.8), stomach (RPKM 7.9) and 19 other tissues.

Summary

This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

PTGER2 Products(1)

mRNA	Protein	Name
NM_000956.4	NP_000947.2	prostaglandin E2 receptor EP2 subtype

PTGER2 Protein Structure

7tm_1

0
100
200
300
358 a.a.

Protein Preferred Names

Protein Names

prostaglandin E2 receptor EP2 subtype

PGE receptor EP2 subtype

PTGER2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83597	Prostaglandin E Receptor EP2 Antibody (YA3342)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat, Cow

Related Diseases

Diseases

Alias

Asthma, Nasal Polyps, And Aspirin Intolerance

Asthma And Nasal Polyps	Asa Triad
Asthma, Aspirin-Induced, Susceptibility To	Asthma, Aspirin-Induced
Asthma, With Nasal Polyps And Aspirin Intolerance	ANPAI
Aia	Aspirin-Intolerant Asthma
Asthma Aspirin-Induced	Nasal Polyps Asthma And Aspirin Sensitivity
Samter Triad	Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Ocular Hypotension

Hypotony Of Eye

Iritis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108560	(+)-Fluprostenol	Activator	97.00%	Unkown
HY-RS11376	PTGER2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-108560A	15(S)-Fluprostenol	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PTGER2	VGNC	VGNC:33502
Macaca mulatta	PTGER2	VGNC	VGNC:76468
Mus musculus	PTGER2	MGD	MGI:97794
Rattus norvegicus	PTGER2	RGD	RGD:620020
Canis familiaris	PTGER2	VGNC	VGNC:45143
Others	PTGER2	NCBI

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