PTGER3 - prostaglandin E receptor 3 Gene

Homo sapiens

Also known as EP3; EP3e; EP3-I; EP3-II; EP3-IV; EP3-VI; PGE2-R; EP3-III; lnc003875

Gene ID: 5733 | Gene type: protein coding

About PTGER3

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:70,852,358-71,047,816 (from NCBI)

This gene has 9 transcripts (splice variants), 197 orthologues and 7 paralogues. Biased expression in endometrium (RPKM 21.7), kidney (RPKM 19.2) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

PTGER3 Products(7)

mRNA	Protein	Name
NM_001126044.2	NP_001119516.1	prostaglandin E2 receptor EP3 subtype isoform 4
NM_198714.2	NP_942007.1	prostaglandin E2 receptor EP3 subtype isoform 4
NM_198715.3	NP_942008.1	prostaglandin E2 receptor EP3 subtype isoform 5
NM_198716.2	NP_942009.1	prostaglandin E2 receptor EP3 subtype isoform 6
NM_198717.2	NP_942010.1	prostaglandin E2 receptor EP3 subtype isoform 7
NM_198718.2	NP_942011.1	prostaglandin E2 receptor EP3 subtype isoform 8
NM_198719.2	NP_942012.1	prostaglandin E2 receptor EP3 subtype isoform 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	31097585	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGER3 Protein Structure

7tm_1

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

prostaglandin E2 receptor EP3 subtype

PGE receptor, EP3 subtype

Related Diseases

Diseases

Alias

Mast Cell Neoplasm

Mastocytoma	Mast Cell Proliferative Disease
Mast Cell Tumor	Benign Mastocytoma

Primary Hypertrophic Osteoarthropathy

Pachydermoperiostosis Syndrome	Osteoarthropathy, Primary Hypertrophic
Pachydermoperiostosis Of Nail	Idiopathic Hypertrophic Osteoarthropathy
Pho

Ocular Hyperemia

Hyperemia Eye

Hyperemia Of Conjunctiva

Fallopian Tube Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of The Fallopian Tube

Mucocele Of Appendix

Appendicele Mucocele	Appendicular Mucocele
Appendiceal Mucocele

Urethral Calculus

Calculus In Urethra	Urethral Stone
Urethrolithiasis	Urethra Calculi Impaction
Urethra Calculus Impaction	Urethra Stone
Calculous Urethritis	Urethral Calculi Impaction
Urethral Calculus Impaction

Severe Cutaneous Adverse Reaction

Stevens-Johnson Syndrome	Toxic Epidermal Necrolysis
Drug-Induced Stevens Johnson Syndrome	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Susceptibility To Severe Cutaneous Adverse Reaction	Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Lyell'S Syndrome	Lyell Syndrome
Severe Cutaneous Adverse Reaction, Susceptibility To	Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To
Hypersensitivity Syndrome, Carbamazepine-Induced	Stevens-Johnson Syndrome, Susceptibility To
Toxic Epidermal Necrolysis, Susceptibility To	Sjs/Ten
Susceptibility To Severe Cutaneous Adverse Reaction Ity To	Mycoplasma-Induced Stevens Johnson Syndrome
Dermatostomatitis, Stevens Johnson Type	Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Sjs-Ten	Toxic Epidermolysis
SJS	Dermatostomatitis Stevens Johnson Type
Ten	Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis]
Ten - [Toxic Epidermal Necrolysis]

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus	PDA1
Pda	Ductus Arteriosus, Patent
Patent Ductus Arteriosus, Susceptibility To	Patent Ductus Botalli
Patency Of The Ductus Arteriosus	Patent Ductus Arteriosus Familial
Ductus Arteriosus Patent	Patent Ductus Arteriosus - Persisting Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11377	PTGER3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PTGER3	VGNC	VGNC:33503
Rattus norvegicus	PTGER3	RGD	RGD:3435
Mus musculus	PTGER3	MGD	MGI:97795
Felis catus	PTGER3	VGNC	VGNC:69141
Macaca mulatta	PTGER3	VGNC	VGNC:76469
Others	PTGER3	NCBI

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