NDRG2 - NDRG family member 2 Gene

Homo sapiens

Also known as SYLD

Gene ID: 57447 | Gene type: protein coding

About NDRG2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,016,763-21,070,872 (from NCBI)

This gene has 77 transcripts (splice variants), 199 orthologues and 3 paralogues. Broad expression in salivary gland (RPKM 217.5), brain (RPKM 177.5) and 19 other tissues.

Summary

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

NDRG2 Products(27)

mRNA	Protein	Name
NM_001282211.2	NP_001269140.1	protein NDRG2 isoform c
NM_001282212.2	NP_001269141.1	protein NDRG2 isoform d
NM_001282213.2	NP_001269142.1	protein NDRG2 isoform b
NM_001282214.2	NP_001269143.1	protein NDRG2 isoform b
NM_001282215.2	NP_001269144.1	protein NDRG2 isoform e
NM_001282216.2	NP_001269145.1	protein NDRG2 isoform f
NM_001320329.2	NP_001307258.1	protein NDRG2 isoform a
NM_001354558.2	NP_001341487.1	protein NDRG2 isoform g
NM_001354559.2	NP_001341488.1	protein NDRG2 isoform a
NM_001354560.2	NP_001341489.1	protein NDRG2 isoform h
NM_001354561.2	NP_001341490.1	protein NDRG2 isoform b
NM_001354562.2	NP_001341491.1	protein NDRG2 isoform a
NM_001354564.2	NP_001341493.1	protein NDRG2 isoform i
NM_001354565.2	NP_001341494.1	protein NDRG2 isoform a
NM_001354566.1	NP_001341495.1	protein NDRG2 isoform a
NM_001354567.2	NP_001341496.1	protein NDRG2 isoform a
NM_001354568.2	NP_001341497.1	protein NDRG2 isoform b
NM_001354569.1	NP_001341498.1	protein NDRG2 isoform b
NM_001354570.2	NP_001341499.1	protein NDRG2 isoform a
NM_016250.3	NP_057334.1	protein NDRG2 isoform b
NM_201535.2	NP_963293.1	protein NDRG2 isoform a
NM_201536.2	NP_963294.1	protein NDRG2 isoform b
NM_201537.2	NP_963831.1	protein NDRG2 isoform a
NM_201538.2	NP_963832.1	protein NDRG2 isoform b
NM_201539.2	NP_963833.1	protein NDRG2 isoform a
NM_201540.2	NP_963834.1	protein NDRG2 isoform a
NM_201541.2	NP_963835.1	protein NDRG2 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21217774	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDRG2 Protein Structure

Ndr

0
100
200
300
371 a.a.

Protein Preferred Names

Protein Names

protein NDRG2

N-myc downstream regulator 2

Related Diseases

Diseases

Alias

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Charcot-Marie-Tooth Disease, Type 4d

Charcot-Marie-Tooth Disease Type 4d	CMT4D
Hmsnl	Hmsn4d
Charcot-Marie-Tooth Neuropathy Type 4d	Hereditary Motor And Sensory Neuropathy Lom Type
Hmsn-Lom	Neuropathy, Hereditary Motor And Sensory, Lom Type
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4d	Charcot-Marie-Tooth Neuropathy, Type 4d
Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4d	Hmsn Lom Type
Hmsn, Lom Type	Hereditary Motor And Sensory Neuropathy, Lom Type
Charcot-Marie-Tooth Disease 4d	Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4d
Hereditary Motor And Sensory Neuropathy Ivd	Hmsn Ivd

Intracranial Meningioma

Meningioma

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100443	PX20606	Agonist	/	Unkown
HY-RS09115	NDRG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NDRG2	MGD	MGI:1352498
Canis familiaris	NDRG2	VGNC	VGNC:43679
Rattus norvegicus	NDRG2	RGD	RGD:621874
Felis catus	NDRG2	VGNC	VGNC:63754
Macaca mulatta	NDRG2	VGNC	VGNC:74953
Bos taurus	NDRG2	VGNC	VGNC:50007

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