AHRR - aryl hydrocarbon receptor repressor Gene

Homo sapiens

Also known as AHH; AHHR; bHLHe77

Gene ID: 57491 | Gene type: protein coding

About AHRR

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:321,714-438,285 (from NCBI)

This gene has 11 transcripts (splice variants), 227 orthologues and 1 paralogue. Broad expression in testis (RPKM 4.1), spleen (RPKM 2.9) and 21 other tissues.

Summary

The protein encoded by this gene participates in the Aryl Hydrocarbon Receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

AHRR Products(2)

mRNA	Protein	Name
NM_001377236.1	NP_001364165.1	aryl hydrocarbon receptor repressor
NM_001377239.1	NP_001364168.1	aryl hydrocarbon receptor repressor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28904176	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AHRR Protein Structure

HLH

PAS

0
200
400
600
701 a.a.

Protein Preferred Names

Protein Names

aryl hydrocarbon receptor repressor

ahR repressor

Related Diseases

Diseases

Alias

Aryl Hydrocarbon Hydroxylase Inducibility

Ahh Inducibility

Ahhi

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00484	AHRR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W517092	1,2,3,4,7,8,9-Heptachlorodibenzofuran		/	Unkown
HY-W775354	1,2,3,4,7,8-Hexachlorodibenzofuran		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AHRR	MGD	MGI:1333776
Macaca mulatta	AHRR	VGNC	VGNC:108143
Felis catus	AHRR	VGNC	VGNC:101455
Canis familiaris	AHRR	VGNC	VGNC:37729
Rattus norvegicus	AHRR	RGD	RGD:1559857

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