XPO5 - exportin 5 Gene

Homo sapiens

Also known as exp5

Gene ID: 57510 | Gene type: protein coding

About XPO5

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,522,334-43,576,038 (from NCBI)

This gene has 12 transcripts (splice variants), 224 orthologues and 1 paralogue. Broad expression in testis (RPKM 18.4), thyroid (RPKM 10.1) and 25 other tissues.

Summary

This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]

XPO5 Products(1)

mRNA	Protein	Name
NM_020750.3	NP_065801.1	exportin-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RISC complex binding	IDA IDA: Inferred from direct assay	19965479	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	21297638	GOA
enables nuclear export signal receptor activity	IMP IMP: Inferred from mutant phenotype	14681208	GOA
contributes to pre-miRNA binding	IDA IDA: Inferred from direct assay	14681208	GOA
enables pre-miRNA binding	IDA IDA: Inferred from direct assay	21297638	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11777942	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	11777942	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	14681208	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in pre-miRNA export from nucleus	IDA IDA: Inferred from direct assay	15613540	GOA
involved in pre-miRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	14681208	GOA
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	11777942	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RISC complex	IDA IDA: Inferred from direct assay	19965479	GOA
part of RNA nuclear export complex	IDA IDA: Inferred from direct assay	14681208	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11777942	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11777942	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XPO5 Protein Structure

Xpo1

0
200
400
600
800
1000
1204 a.a.

Protein Preferred Names

Protein Names

exportin-5

ran-binding protein 21

XPO5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82355	Exportin 5 Antibody (YA2100)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Pleuropulmonary Blastoma

PPB	Ppb Familial Tumor And Dysplasia Syndrome
Ppbftds	Pulmonary Blastoma
Blastoma, Pleuropulmonary	Dicer1 Syndrome
Respiratory Tract Neoplasms

Chromosomal Deletion Syndrome

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15891	XPO5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	XPO5	VGNC	VGNC:67113
Rattus norvegicus	XPO5	RGD	RGD:1311522
Canis familiaris	XPO5	VGNC	VGNC:48462
Macaca mulatta	XPO5	VGNC	VGNC:79081
Bos taurus	XPO5	VGNC	VGNC:36999
Mus musculus	XPO5	MGD	MGI:1913789

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