DISP3 - dispatched RND transporter family member 3 Gene

Homo sapiens

Also known as PTCHD2

Gene ID: 57540 | Gene type: protein coding

About DISP3

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,479,155-11,537,551 (from NCBI)

This gene has 3 transcripts (splice variants), 200 orthologues and 10 paralogues. Biased expression in brain (RPKM 1.6), testis (RPKM 1.4) and 1 other tissue.

Summary

Involved in negative regulation of neuron differentiation; positive regulation of lipid metabolic process; and positive regulation of neural precursor cell proliferation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DISP3 Products(1)

mRNA	Protein	Name
NM_020780.2	NP_065831.1	protein dispatched homolog 3

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	25281927	GOA
involved in positive regulation of lipid metabolic process	IDA IDA: Inferred from direct assay	25281927	GOA
involved in positive regulation of neural precursor cell proliferation	IDA IDA: Inferred from direct assay	25281927	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25281927	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DISP3 Protein Structure

Patched

MMPL

0
300
600
900
1200
1392 a.a.

Protein Preferred Names

Protein Names

protein dispatched homolog 3

dispatched 3

Related Diseases

Diseases

Alias

Scrotum Melanoma

Melanoma Of Scrotum

Cataract 8, Multiple Types

Ccv	Cataract, Congenital, Volkmann Type
CTRCT8	Cataract 8 Multiple Types
Cataract Congenital Volkmann Type	Cutaneous Collagenous Vasculopathy

Anus Benign Neoplasm

Anal Neoplasm	Anal Tumors
Neoplasm Of Anus	Anus Neoplasms

Actinomycosis

Actinomycetoma	Boil
Canaliculitis	Actinomycotic Infection
Actinomycotic Madura Foot	Keratoactinomycosis
Furuncle	Actinomycotic Mycetema
Actinomycotic Mycetoma Of Foot	Madura Foot Due To Actinomadura
Actinomyces Israeli	Actinomycetes
Anaerobic Actinomyces Infection	Actinomycotic Infection Of Unspecified Site
Actinomycosis Nos	Actinomycotic Node
Actinomyces Infection	Actinomycotic Mycetoma
Mycetoma Due To Filamentous Bacteria

Scrotum Neoplasm

Malignant Tumour Of Scrotum	Malignant Scrotal Neoplasm
Malignant Tumor Of Scrotum	Neoplasm Of Scrotum
Scrotal Ca	Scrotal Tumor
Scrotum Cancer	Cancer Of Scrotum
Malignant Neoplasm Of Scrotum	Scrotal Cancer
Malignant Scrotal Tumour	Malignant Neoplasm Of Skin Of Scrotum
Primary Malignant Neoplasm Of Scrotum

Zika Virus Congenital Syndrome

Zikv Congenital Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03784	DISP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DISP3	RGD	RGD:1305820
Mus musculus	DISP3	MGD	MGI:2444403
Felis catus	DISP3	VGNC	VGNC:61504
Bos taurus	DISP3	VGNC	VGNC:28076
Canis familiaris	DISP3	VGNC	VGNC:39968
Macaca mulatta	DISP3	VGNC	VGNC:106348

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