SIPA1L2 - signal induced proliferation associated 1 like 2 Gene

Homo sapiens

Also known as SPAL2; SPAR2

Gene ID: 57568 | Gene type: protein coding

About SIPA1L2

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:232,397,965-232,630,496 (from NCBI)

This gene has 11 transcripts (splice variants), 209 orthologues and 6 paralogues. Ubiquitous expression in heart (RPKM 11.7), placenta (RPKM 10.4) and 24 other tissues.

Summary

This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]

SIPA1L2 Products(2)

mRNA	Protein	Name
NM_001377488.1	NP_001364417.1	signal-induced proliferation-associated 1-like protein 2 isoform 2
NM_020808.5	NP_065859.3	signal-induced proliferation-associated 1-like protein 2 isoform 1

SIPA1L2 Protein Structure

Rap_GAP

PDZ

SPAR_C

0
300
600
900
1200
1500
1722 a.a.

Protein Preferred Names

Protein Names

signal-induced proliferation-associated 1-like protein 2

SIPA1-like protein 2

Related Diseases

Diseases

Alias

Warburg Micro Syndrome 4

WARBM4

Micro Syndrome 4

Cortical Dysplasia, Complex, With Other Brain Malformations 6

Complex Cortical Dysplasia With Other Brain Malformations 6	CDCBM6
Cdcbm56	Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12930	SIPA1L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SIPA1L2	VGNC	VGNC:65154
Rattus norvegicus	SIPA1L2	RGD	RGD:1306269
Bos taurus	SIPA1L2	VGNC	VGNC:34629
Canis familiaris	SIPA1L2	VGNC	VGNC:46181
Mus musculus	SIPA1L2	MGD	MGI:2676970
Macaca mulatta	SIPA1L2	VGNC	VGNC:106494

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